含氟精神药理学药物：通过氟-19核磁共振进行无创观察

Fluorinated psychopharmacological agents: noninvasive observation by fluorine-19 nuclear magnetic resonance.

作者信息

Bartels M, Albert K, Kruppa G, Mann K, Schroth G, Tabarelli S, Zabel M

出版信息

Psychiatry Res. 1986 Jul;18(3):197-201. doi: 10.1016/0165-1781(86)90106-x.

Abstract

Fluorinated psychopharmacological agents were measured with fluorine-19 nuclear magnetic resonance spectroscopy in the brain of intact rats that had been treated with fluphenazine. These in vivo experiments were compared to in vitro measurements of fluphenazine-treated rats. A high-field shift was observed in both in vivo and in vitro measurements. On the basis of the in vitro measurements, fluphenazine concentration in the brains of treated rats was estimated. Our observations demonstrate the feasibility of this technique for determining fluorinated neuroleptics in live mammals.

摘要

用氟-19核磁共振波谱法测定了经氟奋乃静处理的完整大鼠脑内的氟化精神药理制剂。将这些体内实验与氟奋乃静处理大鼠的体外测量结果进行了比较。在体内和体外测量中均观察到高场位移。根据体外测量结果，估算了处理大鼠脑内的氟奋乃静浓度。我们的观察结果证明了该技术在活体哺乳动物中测定氟化抗精神病药物的可行性。