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瘤内注射博来霉素:一种治疗结膜淋巴管瘤的方法。

Intralesional bleomycin: A treatment modality for conjunctival lymphangioma.

作者信息

Bansal Smriti, Das Sima

机构信息

Department of Oculoplasty, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

出版信息

Oman J Ophthalmol. 2020 Feb 17;13(1):43-45. doi: 10.4103/ojo.OJO_44_2019. eCollection 2020 Jan-Apr.

DOI:10.4103/ojo.OJO_44_2019
PMID:32174741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7050451/
Abstract

Lymphangioma is a benign hamartomatous lesion of vascular system which frequently involves orbit and ocular adnexa. A 35-year-old male patient presented with a subconjunctival mass extending from limbus to fornices. There was a history of recurrent swellings following episodes of upper respiratory tract infection. Bleomycin is an antineoplastic agent which acts on endothelial cells of the vascular channels, helps in collapsing the cystic cavity, and prevents its recurrence. We report a case where only bleomycin injection has been used intralesionally at multiple spots and patients have shown good cosmetic outcome without any recurrence noted after 1 year of follow-up.

摘要

淋巴管瘤是一种血管系统的良性错构瘤性病变,常累及眼眶和眼附属器。一名35岁男性患者出现从角膜缘延伸至穹窿部的结膜下肿物。有上呼吸道感染发作后反复肿胀的病史。博来霉素是一种抗肿瘤药物,作用于血管通道的内皮细胞,有助于使囊腔塌陷并防止其复发。我们报告一例仅在病变内多个部位注射博来霉素的病例,患者术后美容效果良好,随访1年未见复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5acb/7050451/e16f0843a958/OJO-13-43-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5acb/7050451/05f92c0fb959/OJO-13-43-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5acb/7050451/e16f0843a958/OJO-13-43-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5acb/7050451/05f92c0fb959/OJO-13-43-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5acb/7050451/e16f0843a958/OJO-13-43-g002.jpg

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本文引用的文献

1
A prospective study of the role of intralesional bleomycin in orbital lymphangioma.关于瘤内注射博来霉素在眼眶淋巴管瘤中作用的前瞻性研究。
J AAPOS. 2017 Apr;21(2):146-151. doi: 10.1016/j.jaapos.2017.03.007. Epub 2017 Mar 12.
2
Intralesional Bleomycin as an Adjunct Therapeutic Modality in Eyelid and Extraocular Malignancies and Tumors.局部注射博来霉素作为眼睑及眼外恶性肿瘤和肿瘤的辅助治疗方式
Middle East Afr J Ophthalmol. 2015 Oct-Dec;22(4):410-4. doi: 10.4103/0974-9233.167822.
3
Surgical management, outcomes, and recurrence rate of orbital lymphangiomas.
眼眶淋巴管瘤的手术治疗、疗效及复发率
J Clin Neurosci. 2015 May;22(5):877-82. doi: 10.1016/j.jocn.2014.11.002. Epub 2015 Mar 18.
4
Successful treatment of orbital lymphangioma with intralesional bleomycin and application of continuous negative pressure.采用瘤内注射博来霉素及持续负压吸引成功治疗眼眶淋巴管瘤。
Korean J Ophthalmol. 2015 Feb;29(1):70-2. doi: 10.3341/kjo.2015.29.1.70.
5
Intralesional bleomycin: a potential treatment for refractory orbital lymphangiomas.瘤内博来霉素:一种治疗难治性眼眶淋巴管瘤的潜在方法。
Ophthalmic Plast Reconstr Surg. 2014 May-Jun;30(3):e65-7. doi: 10.1097/IOP.0b013e31829bb4a9.
6
Intralesional bleomycin in lymphangioma: an effective and safe non-operative modality of treatment.淋巴管瘤内注射博来霉素:一种有效且安全的非手术治疗方式。
J Cutan Aesthet Surg. 2012 Apr;5(2):133-6. doi: 10.4103/0974-2077.99456.
7
Intralesional bleomycin for the treatment of periocular capillary hemangiomas.瘤内注射平阳霉素治疗眼周毛细血管血管瘤。
Indian J Ophthalmol. 2012 Jul;60(4):326-8. doi: 10.4103/0301-4738.98722.
8
Conjunctival lymphangioma: a case report and brief review of the literature.结膜淋巴管瘤:一例报告并文献简要综述
Case Rep Ophthalmol Med. 2012;2012:836573. doi: 10.1155/2012/836573. Epub 2012 May 17.
9
Lymphangiomas of the ocular adnexa. An analysis of sixty-two cases.
Am J Ophthalmol. 1961 Mar;51:481-509. doi: 10.1016/0002-9394(61)92094-3.
10
Orbital lymphangioma: an analysis of 26 patients.眼眶淋巴管瘤:26例患者分析
Br J Ophthalmol. 1999 Jan;83(1):76-80. doi: 10.1136/bjo.83.1.76.