Aljumaah Mashael R, Alkhulaifi Manal M, Abudabos Alaeldein M
Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
J Poult Sci. 2020 Jan 25;57(1):45-54. doi: 10.2141/jpsa.0190042.
Antibiotic growth promoters (AGPs) have been used for many years as supplements in various livestock diets, including those for poultry. However, the use of AGPs in feed was also associated with an increasing number of antibiotic-resistant bacteria in livestock. In this study, the antibacterial efficacies of eight commercially available non-AGPs suitable for use in poultry were investigated. Assessments included a combination of antibacterial activity assays and estimations of the minimal inhibitory and bactericidal concentrations along with scanning electron microscopy analysis. The results showed that the probiotic, CloStat exerted a bacteriostatic effect against all tested bacteria, namely Typhimurium, , and , whereas Gallipro Tect and Bacillus Blend demonstrated bacteriostatic activity towards most of the pathogens tested. Other commercial non-AGPs, Sangrovit, Fysal, and Mix oil blend showed a stronger or equal antibacterial activity compared to the positive control (AGP Maxus G100) againsts all bacteria tested, except . Nor-Spice AB and Varium™ did not show any significant effect against the tested bacteria. Several of the tested AGP substitutes exhibited good antibacterial efficiency against pathogenic bacteria and thus may be good candidates for second-stage investigations into reducing pathogen colonization in broilers.
抗生素生长促进剂（AGPs）多年来一直作为各种家畜饲料（包括家禽饲料）的添加剂使用。然而，饲料中使用AGPs也与家畜体内越来越多的抗生素抗性细菌有关。在本研究中，对八种适用于家禽的市售非AGPs的抗菌效果进行了研究。评估包括抗菌活性测定、最低抑菌浓度和杀菌浓度的估计以及扫描电子显微镜分析。结果表明，益生菌CloStat对所有测试细菌（即鼠伤寒沙门氏菌等）都有抑菌作用，而Gallipro Tect和芽孢杆菌混合物对大多数测试病原体都有抑菌活性。其他市售非AGPs，如Sangrovit、Fysal和混合油混合物，与阳性对照（AGP Maxus G100）相比，对除[某细菌]外的所有测试细菌都表现出更强或相当的抗菌活性。Nor-Spice AB和Varium™对测试细菌没有显示出任何显著效果。几种测试的AGP替代品对病原菌表现出良好的抗菌效率，因此可能是进一步研究减少肉鸡病原体定植的良好候选物。
