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HIV-Infected or -Exposed Children Exhibit Lower Immunogenicity to Hepatitis B Vaccine in Yaoundé, Cameroon: An Appeal for Revised Policies in Tropical Settings?在喀麦隆雅温得，感染或接触过艾滋病毒的儿童对乙肝疫苗的免疫原性较低：呼吁在热带地区修订政策？
PLoS One. 2016 Sep 22;11(9):e0161714. doi: 10.1371/journal.pone.0161714. eCollection 2016.
2
Recombinant Hepatitis B Vaccine Adjuvanted With AS04 in Dialysis Patients: A Prospective Cohort Study.透析患者中使用AS04佐剂的重组乙型肝炎疫苗：一项前瞻性队列研究。
Kidney Blood Press Res. 2015;40(6):584-92. doi: 10.1159/000368534. Epub 2015 Nov 15.
3
Characterization of an age-response relationship to GSK's recombinant hepatitis B vaccine in healthy adults: An integrated analysis.健康成年人中GSK重组乙型肝炎疫苗年龄反应关系的特征：一项综合分析。
Hum Vaccin Immunother. 2015;11(7):1726-9. doi: 10.1080/21645515.2015.1039758.
4
Repeated vaccinations do not improve specific immune defenses against Hepatitis B in non-responder health care workers.重复接种疫苗并不能增强无反应医护人员对乙型肝炎的特异性免疫防御能力。
Vaccine. 2014 Dec 5;32(51):6902-6910. doi: 10.1016/j.vaccine.2014.10.066. Epub 2014 Nov 5.
5
Genetic polymorphisms of CXCR5 and CXCL13 are associated with non-responsiveness to the hepatitis B vaccine.CXCR5和CXCL13的基因多态性与对乙肝疫苗无反应性相关。
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6
CDC guidance for evaluating health-care personnel for hepatitis B virus protection and for administering postexposure management.疾病预防控制中心关于评估乙型肝炎病毒保护的卫生保健人员以及实施接触后管理的指南。
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7
Is obesity a risk factor for vaccine non-responsiveness?肥胖是否是疫苗无应答的一个危险因素？
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8
Immune response to hepatitis B vaccine in a group of health care workers in Sri Lanka.斯里兰卡一组卫生保健工作者对乙肝疫苗的免疫应答。
Int J Infect Dis. 2013 Nov;17(11):e1078-9. doi: 10.1016/j.ijid.2013.04.009. Epub 2013 Jun 28.
9
The gut microbiome and obesity.肠道微生物群与肥胖
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10
The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice.饮食对人类肠道微生物组的影响：在人源化无菌小鼠中的宏基因组分析。
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医护人员中乙型肝炎疫苗疗效的危险因素。

Risk factors of the efficacy of hepatitis B vaccine in health-care workers.

作者信息

Salehi Hassan, Salehi Marzieh, Kalbasi Nader, Salehi Maryam, Sharifian Jalil, Salehi Mohammad Mahdi

机构信息

Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Infectious Diseases, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

J Res Med Sci. 2020 Feb 20;25:15. doi: 10.4103/jrms.JRMS_1054_18. eCollection 2020.

DOI:10.4103/jrms.JRMS_1054_18
PMID:32174987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7053165/
Abstract

BACKGROUND

Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%-10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health-care workers.

MATERIALS AND METHODS

This was a descriptive study which was implemented among 140 of medical and dental staff working as health-care workers who were low responder after vaccination entered the study.

RESULTS

Age (>40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors.

CONCLUSION

In the high-risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.

摘要

背景

传统的乙肝病毒疫苗接种在全球约5%-10%的人口中未能实现有效保护。不同因素影响乙肝疫苗的免疫原性。本研究旨在评估医护人员中的这些因素。

材料与方法

这是一项描述性研究，在140名医护人员（医学和牙科工作人员）中开展，这些人员接种疫苗后反应低下，进入本研究。

结果

年龄（>40岁）、体重（体重指数>25）、免疫缺陷疾病（原发性免疫缺陷和免疫抑制药物）、糖尿病和吸烟是重要因素。

结论

在乙肝疾病高危人群中，接种疫苗时必须评估免疫原性的危险因素，并在接种后检查抗体滴度。