医护人员中乙型肝炎疫苗疗效的危险因素。
Risk factors of the efficacy of hepatitis B vaccine in health-care workers.
作者信息
Salehi Hassan, Salehi Marzieh, Kalbasi Nader, Salehi Maryam, Sharifian Jalil, Salehi Mohammad Mahdi
机构信息
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Infectious Diseases, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2020 Feb 20;25:15. doi: 10.4103/jrms.JRMS_1054_18. eCollection 2020.
BACKGROUND
Conventional hepatitis B virus vaccination fails to achieve efficient protection in about 5%-10% of the world population. Different factors influence the immunogenicity of hepatitis B vaccine. This study aimed to evaluate these factors in health-care workers.
MATERIALS AND METHODS
This was a descriptive study which was implemented among 140 of medical and dental staff working as health-care workers who were low responder after vaccination entered the study.
RESULTS
Age (>40 years), weight (body mass index >25), immunodeficiency diseases, (primary immune deficiency and immunosuppressant drugs), diabetes mellitus, and smoking were the important factors.
CONCLUSION
In the high-risk group of hepatitis B disease, the risk factors of immunogenicity must be evaluated at vaccination and check titers of antibody after vaccination.
背景
传统的乙肝病毒疫苗接种在全球约5%-10%的人口中未能实现有效保护。不同因素影响乙肝疫苗的免疫原性。本研究旨在评估医护人员中的这些因素。
材料与方法
这是一项描述性研究，在140名医护人员（医学和牙科工作人员）中开展，这些人员接种疫苗后反应低下，进入本研究。
结果
年龄（>40岁）、体重（体重指数>25）、免疫缺陷疾病（原发性免疫缺陷和免疫抑制药物）、糖尿病和吸烟是重要因素。
结论
在乙肝疾病高危人群中，接种疫苗时必须评估免疫原性的危险因素，并在接种后检查抗体滴度。
Zotero 插件