Vafadar Asma, Shabaninejad Zahra, Movahedpour Ahmad, Fallahi Farzaneh, Taghavipour Mona, Ghasemi Younes, Akbari Maryam, Shafiee Alimohammad, Hajighadimi Sarah, Moradizarmehri Sanaz, Razi Ebrahim, Savardashtaki Amir, Mirzaei Hamed
1Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
2Department of Nanotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Cell Biosci. 2020 Mar 10;10:32. doi: 10.1186/s13578-020-00397-0. eCollection 2020.
Ovarian cancer is known as a serious malignancy that affects women's reproductive tract and can considerably threat their health. A wide range of molecular mechanisms and genetic modifications have been involved in ovarian cancer pathogenesis making it difficult to develop effective therapeutic platforms. Hence, discovery and developing new therapeutic approaches are required. Medicinal plants, as a new source of drugs, could potentially be used alone or in combination with other medicines in the treatment of various cancers such as ovarian cancer. Among various natural compounds, quercetin has shown great anti-cancer and anti-inflammatory properties. In vitro and in vivo experiments have revealed that quercetin possesses a cytotoxic impact on ovarian cancer cells. Despite obtaining good results both in vitro and in vivo, few clinical studies have assessed the anti-cancer effects of quercetin particularly in the ovarian cancer. Therefore, it seems that further clinical studies may introduce quercetin as therapeutic agent alone or in combination with other chemotherapy drugs to the clinical setting. Here, we not only summarize the anti-cancer effects of quercetin but also highlight the therapeutic effects of quercetin in the ovarian cancer.
卵巢癌是一种严重的恶性肿瘤，会影响女性生殖道，并对她们的健康构成重大威胁。卵巢癌的发病机制涉及多种分子机制和基因修饰，这使得开发有效的治疗平台变得困难。因此，需要发现和开发新的治疗方法。药用植物作为一种新的药物来源，有可能单独或与其他药物联合用于治疗各种癌症，如卵巢癌。在各种天然化合物中，槲皮素已显示出强大的抗癌和抗炎特性。体外和体内实验表明，槲皮素对卵巢癌细胞具有细胞毒性作用。尽管在体外和体内都取得了良好的结果，但很少有临床研究评估槲皮素的抗癌作用，尤其是在卵巢癌方面。因此，进一步的临床研究似乎可能会将槲皮素单独或与其他化疗药物联合作为治疗药物引入临床。在这里，我们不仅总结了槲皮素的抗癌作用，还强调了槲皮素在卵巢癌中的治疗作用。
