Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, No. 29 Nicolae Jiga Street, 410028 Oradea, Romania.
Department of Surgical Discipline, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
Int J Mol Sci. 2024 Nov 11;25(22):12091. doi: 10.3390/ijms252212091.
The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize the existing research on quercetin's potential health benefits, therapeutic properties, and effectiveness in disease prevention and treatment. In addition to evaluating quercetin's potential for drug development with fewer side effects and lower toxicity, this type of review attempts to collect scientific evidence addressing quercetin's roles as an antioxidant, anti-inflammatory, antibacterial, and anticancer agent. In the first part, we analyze various flavonoid compounds, focusing on their chemical structure, classification, and natural sources. We highlight their most recent biological activities as reported in the literature. Among these compounds, we pay special attention to quercetin, detailing its chemical structure, physicochemical properties, and process of biosynthesis in plants. We also present natural sources of quercetin and emphasize its health benefits, such as its antioxidant and anti-inflammatory effects. Additionally, we discuss methods to enhance its bioavailability, analyzing the latest and most effective delivery systems based on quercetin.
本次对类黄酮次级代谢产物槲皮素的系统评价主要目的是评估和总结现有的关于槲皮素在健康益处、治疗特性和疾病预防与治疗方面的研究。除了评估具有较少副作用和较低毒性的开发药物的潜力外，这种类型的综述还试图收集有关槲皮素作为抗氧化剂、抗炎剂、抗菌剂和抗癌剂的作用的科学证据。在第一部分中，我们分析了各种类黄酮化合物，重点关注它们的化学结构、分类和天然来源。我们强调了文献中报道的它们最近的生物活性。在这些化合物中，我们特别关注槲皮素，详细介绍其化学结构、物理化学性质和在植物中的生物合成过程。我们还介绍了槲皮素的天然来源，并强调了它的健康益处，如抗氧化和抗炎作用。此外，我们还讨论了提高其生物利用度的方法，分析了基于槲皮素的最新且最有效的输送系统。
