在分析性治疗中断期间减轻艾滋病毒传播风险的协作性多学科方法。
A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption.
作者信息
Peluso Michael J, Dee Lynda, Campbell Danielle, Taylor Jeff, Hoh Rebecca, Rutishauser Rachel L, Sauceda John, Deeks Steven G, Dubé Karine
机构信息
Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, San Francisco, CA, USA.
AIDS Action Baltimore, Baltimore, MD, USA.
出版信息
J Virus Erad. 2020 Feb 20;6(1):34-37. doi: 10.1016/S2055-6640(20)30009-1.
Abstract
Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s). Two documented HIV transmissions occurring in the context of ATIs have been recently reported, but recommendations for mitigating the risk of such events during ATIs are limited. We outline a practical approach to risk mitigation during ATI studies and describe strategies we are utilising in an upcoming clinical trial that may be applicable to other centres.
摘要
分析性治疗中断（ATIs）目前是评估旨在诱导持续停止抗逆转录病毒治疗（ART）实现缓解的实验性干预措施在与HIV治愈相关试验中影响的标准方法。ATIs对研究参与者及其性伴侣都存在重大风险。最近有两份记录在案的在ATIs期间发生的HIV传播报告，但关于在ATIs期间降低此类事件风险的建议有限。我们概述了在ATI研究期间降低风险的实用方法，并描述了我们在即将开展的一项临床试验中正在采用的策略，这些策略可能适用于其他中心。
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