Meanley Steven, Carter William B, Short William R, Metzger David S, Onorato Amy, Montaner Luis J, Dubé Karine
Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA.
BEAT-HIV Community Advisory Board, Philadelphia, Pennsylvania, USA.
Open Forum Infect Dis. 2024 Nov 19;11(12):ofae687. doi: 10.1093/ofid/ofae687. eCollection 2024 Dec.
Ethical patient outreach is critical for engaging patients with HIV in HIV cure-directed research. We sought to examine HIV clinical providers' awareness of current HIV cure-directed research strategies investigated through the Martin Delaney Collaboratories (MDC) and providers' attitudes toward patient outreach for HIV cure-directed research and to identify opportunities for clinical provider education on MDC research strategies.
We conducted a 1-time, cross-sectional, web-based survey with 64 HIV clinical providers (physicians, physician assistants, and nurses) in Philadelphia. A descriptive analysis was generated to determine clinical providers' awareness of MDC research strategies and attitudes toward patient outreach. Bivariate analyses were conducted to evaluate differences in awareness and attitudes by provider characteristics.
Most providers were aware of MDC strategies, and nearly three-fourths of providers reported familiarity with 1 of the 2 Philadelphia MDC research programs. Providers overwhelmingly endorsed the need for clinicians to assist with patient outreach for HIV cure-directed research and were willing to recommend patients to participate. Enthusiasm for patient outreach waned if a study required a patient to undergo analytic treatment interruptions (ATIs). Providers identified preferred resources for receiving HIV cure-directed research updates, including webinars with continuing education credit and conferences.
Our study's findings advocate for added investment toward developing resources that better engage clinical providers about HIV cure-directed research updates and ongoing studies, including the importance of ATIs. As gatekeepers to patient participation on HIV cure-directed studies, added efforts to increase provider knowledge of specific HIV cure-directed research will advance patient education and ethical outreach.
符合伦理的患者宣传对于促使感染艾滋病毒的患者参与以治愈为导向的艾滋病毒研究至关重要。我们试图调查艾滋病毒临床医护人员对通过马丁·德莱尼合作项目（MDC）所研究的当前以治愈为导向的艾滋病毒研究策略的认知，以及他们对以治愈为导向的艾滋病毒研究患者宣传的态度，并确定针对临床医护人员开展MDC研究策略教育的机会。
我们对费城的64名艾滋病毒临床医护人员（医生、医师助理和护士）进行了一次基于网络的横断面调查。进行描述性分析以确定临床医护人员对MDC研究策略的认知以及对患者宣传的态度。进行双变量分析以评估不同医护人员特征在认知和态度方面的差异。
大多数医护人员知晓MDC策略，近四分之三的医护人员表示熟悉费城的2个MDC研究项目中的1个。医护人员压倒性地认可临床医生需要协助开展以治愈为导向的艾滋病毒研究的患者宣传工作，并愿意推荐患者参与。如果一项研究要求患者接受分析性治疗中断（ATI），那么对患者宣传的热情就会降低。医护人员确定了获取以治愈为导向的艾滋病毒研究最新信息的首选资源，包括有继续教育学分的网络研讨会和会议。
我们研究的结果主张增加投入，以开发更好地让临床医护人员了解以治愈为导向的艾滋病毒研究最新信息和正在进行的研究的资源，包括ATI的重要性。作为患者参与以治愈为导向的艾滋病毒研究的把关人，加大力度提高医护人员对特定以治愈为导向的艾滋病毒研究的了解，将推动患者教育和符合伦理的宣传工作。
