Sanford Nina N, Giovannucci Edward L, Ahn Chul, Dee Edward C, Mahal Brandon A
Department of Radiation Oncology, University of Texas Southwestern, Dallas, TX, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
J Gastrointest Oncol. 2020 Feb;11(1):121-126. doi: 10.21037/jgo.2019.12.07.
The etiology behind the increasing incidence of early onset colorectal cancer (EOCRC) are incompletely elucidated, but could be attributed in part to lifestyle factors. We assessed the association between obesity and colorectal cancer (CRC) in younger versus older adults in the National Health Institute Survey. Multivariable logistic regression defined adjusted odds ratios (AORs) and associated 95% confidence intervals (CIs) for CRC including an age (< ≥50 years) BMI (< ≥30.0 kg/m) interaction term. Among 583,511 study participants with a total of 3,173 CRC cases, there was a significant ageBMI interaction term (P=0.02) such that for participants aged 18-49 years, BMI ≥30.0 kg/m was associated with diagnosis of CRC (34.1% 27.4%, AOR 1.39, 95% CI: 1.00-1.92) but not for participants aged ≥50 (29.6% 31.4%, AOR 0.93, 95% CI: 0.85-1.03). Obese BMI appears to be associated with diagnosis of EOCRC, thus weight control by early adulthood, among other healthy lifestyle behaviors, could serve as potential risk reduction strategies for CRC.
早发性结直肠癌（EOCRC）发病率上升背后的病因尚未完全阐明，但部分可归因于生活方式因素。我们在美国国立卫生研究院调查中评估了年轻人与老年人中肥胖与结直肠癌（CRC）之间的关联。多变量逻辑回归确定了CRC的校正优势比（AOR）及相关的95%置信区间（CI），包括年龄（<≥50岁）体重指数（<≥30.0kg/m）交互项。在583,511名研究参与者（共3173例CRC病例）中，存在显著的年龄体重指数交互项（P = 0.02），即对于18 - 49岁的参与者，体重指数≥30.0kg/m与CRC诊断相关（34.1% 27.4%，AOR 1.39，95%CI：1.00 - 1.92），但对于≥50岁的参与者则不然（29.6% 31.4%，AOR 0.93，95%CI：0.85 - 1.03）。肥胖的体重指数似乎与EOCRC诊断相关，因此在成年早期控制体重以及采取其他健康的生活方式行为，可作为降低CRC潜在风险的策略。
