Review of functional materials for potential use as wearable infection sensors in limb prostheses.

The fundamental goal of prosthesis is to achieve optimal levels of performance and enhance the quality of life of amputees. Socket type prostheses have been widely employed despite their known drawbacks. More recently, the advent of osseointegrated prostheses have demonstrated potential to be a better alternative to socket prosthesis eliminating most of the drawbacks of the latter. However, both socket and osseointegrated limb prostheses are prone to superficial infections during use. Infection prone skin lesions from frictional rubbing of the socket against the soft tissue are a known problem of socket type prosthesis. Osseointegration, on the other hand, results in an open wound at the implant-stump interface. The integration of infection sensors in prostheses to detect and prevent infections is proposed to enhance quality of life of amputees. Pathogenic volatiles having been identified to be a potent stimulus, this paper reviews the current techniques in the field of infection sensing, specifically focusing on identifying portable and flexible sensors with potential to be integrated into prosthesis designs. Various sensor architectures including but not limited to sensors fabricated from conducting polymers, carbon polymer composites, metal oxide semiconductors, metal organic frameworks, hydrogels and synthetic oligomers are reviewed. The challenges and their potential integration pathways that can enhance the possibilities of integrating these sensors into prosthesis designs are analysed.