Huang Yuzhou, Xiao Yi, Zhang Xingyu, Li Jie, Chen Xiang, Shen Minxue
Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Hunan Engineering Research Center of Skin Health and Disease, Central South University, Changsha, China.
Front Med (Lausanne). 2020 Feb 27;7:39. doi: 10.3389/fmed.2020.00039. eCollection 2020.
Chronic urticaria (CU) is a frequently occurring skin condition associated with many psychological factors, but the effect size of associations varied in literature. To perform a systematic review and meta-analysis on the associations of CU with the symptoms of depression and anxiety. According to a pre-specified protocol, we systematically searched articles published in PubMed, Web of Science, CNKI, and CQVIP databases between January 2000 and January 2019. Pooled estimates in terms of odds ratios (ORs) or standardized mean differences (SMDs) were calculated according to outcome measures. Subgroup analysis by disease subtypes and tool of measurement, and sensitivity analysis were performed. Risk of bias and quality of studies were evaluated. Twelve studies were selected for the systematic review. The ORs were 3.99 [95% confidence interval (CI): 3.24-4.91, < 0.001] for anxiety and 2.94 (95% CI: 2.42-3.58, < 0.001) for depression. The SMDs of severity were 0.98 for anxiety (95% CI: 0.76-1.200, < 0.001) and 0.84 for depression (95% CI: 0.59-1.10, < 0.001). Subgroup analysis by disease subtypes and tool of measurement showed variations in effect size, where chronic spontaneous urticaria showed greater effects on anxiety (OR = 6.62, 95% CI: 3.67-11.95, < 0.001) and depression (OR = 6.13, 95% CI: 2.31-16.31, < 0.001). Sensitivity analysis demonstrated consistent results. CU is associated with higher risks of anxiety and depression.
慢性荨麻疹（CU）是一种常发性皮肤病，与多种心理因素相关，但相关文献中关联的效应量有所不同。为了对CU与抑郁和焦虑症状的关联进行系统评价和荟萃分析。根据预先制定的方案，我们系统检索了2000年1月至2019年1月期间发表在PubMed、科学网、中国知网和维普数据库中的文章。根据结局指标计算比值比（OR）或标准化均数差（SMD）的合并估计值。进行了疾病亚型和测量工具的亚组分析以及敏感性分析。评估了研究的偏倚风险和质量。12项研究被选入系统评价。焦虑的OR为3.99[95%置信区间（CI）：3.24 - 4.91，P < 0.001]，抑郁的OR为2.94（95%CI：2.42 - 3.58，P < 0.001）。焦虑严重程度的SMD为0.98（95%CI：0.76 - 1.200，P < 0.001），抑郁的SMD为0.84（95%CI：0.59 - 1.1０，P < 0.001）。疾病亚型和测量工具的亚组分析显示效应量存在差异，其中慢性自发性荨麻疹对焦虑（OR = 6.62，95%CI：3.67 - 11.95，P < 0.001）和抑郁（OR = 6.13，95%CI：2.31 - 16.31，P < 0.001）的影响更大。敏感性分析显示结果一致。CU与更高的焦虑和抑郁风险相关。
