Dai Ru, Lin BingJiang, Zhang Xuetong, Lou Yuchen, Xu Suling
Department of Dermatology, Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, 310009, Zhejiang, People's Republic of China.
Department of Dermatology, Ningbo First Hospital, Zhejiang University, No. 59, Liuting Street, Ningbo, 315010, Zhejiang, China.
Dermatol Ther (Heidelb). 2021 Dec;11(6):2089-2105. doi: 10.1007/s13555-021-00613-w. Epub 2021 Oct 18.
Depression and anxiety are common among people with rosacea. However, the exact magnitude of the prevalence rate and odds ratios (ORs) for depression and anxiety, respectively, in rosacea patients is unclear, and no systematic review or meta-analysis of published data has yet been performed. We therefore performed as systematic review and meta-analysis to determine the prevalence rates and ORs for depression and anxiety in rosacea patients.
We performed a systematic search of the PubMed, Embase and Medline databases for all observational studies published up to October 2020 that reported the prevalence rates and ORs for depression and anxiety in patients with rosacea. The primary outcome measures were prevalence rates and ORs for depression and anxiety in patients with rosacea. Heterogeneity across studies was assessed with the I statistic. Sources of heterogeneity were explored through subgroup and meta-regression analyses.
A total of 14 studies involving 14,134,021 patients with rosacea were included in the systematic review and meta-analysis. The pooled prevalence of depression was 19.6% (95% confidence interval [CI] 15.0-24.3%) and that of anxiety was 15.6% (95% CI 11.8-19.3%). The prevalence of depression and anxiety was significantly lower in studies using clinical criteria to diagnose depression and anxiety (9.2 and 10.2%, respectively) than in those studies using screening tools (26.2% [P < 0.01] and 22.7% [P = 0.03], respectively). The methodological quality of the included studies greatly contributed to the heterogeneity. Patients with rosacea were more likely to experience depression (OR 2.21, 95% CI 1.79-2.72) and anxiety (OR 2.31, 95% CI 1.56-3.44) than healthy controls.
This systematic review and meta-analysis indicates that patients with rosacea are at a higher risk of experiencing depression and anxiety. More efforts are warranted to recognize and manage depression and anxiety in patients with rosacea.
抑郁症和焦虑症在酒渣鼻患者中很常见。然而，酒渣鼻患者中抑郁症和焦虑症的患病率及优势比（OR）的确切程度尚不清楚，且尚未对已发表的数据进行系统评价或荟萃分析。因此，我们进行了一项系统评价和荟萃分析，以确定酒渣鼻患者中抑郁症和焦虑症的患病率及OR。
我们对PubMed、Embase和Medline数据库进行了系统检索，以查找截至2020年10月发表的所有观察性研究，这些研究报告了酒渣鼻患者中抑郁症和焦虑症的患病率及OR。主要结局指标为酒渣鼻患者中抑郁症和焦虑症的患病率及OR。采用I统计量评估研究间的异质性。通过亚组分析和meta回归分析探索异质性来源。
系统评价和荟萃分析共纳入14项研究，涉及14,134,021名酒渣鼻患者。抑郁症的合并患病率为19.6%（95%置信区间[CI] 15.0 - 24.3%），焦虑症的合并患病率为15.6%（95% CI 11.8 - 19.3%）。使用临床标准诊断抑郁症和焦虑症的研究中，抑郁症和焦虑症的患病率（分别为9.2%和10.2%）显著低于使用筛查工具的研究（分别为26.2% [P < 0.01]和22.7% [P = 0.03]）。纳入研究的方法学质量对异质性有很大影响。与健康对照相比，酒渣鼻患者更易患抑郁症（OR 2.21，95% CI 1.79 - 2.72）和焦虑症（OR 2.31，95% CI 1.56 - 3.44）。
这项系统评价和荟萃分析表明，酒渣鼻患者患抑郁症和焦虑症的风险更高。有必要付出更多努力来识别和管理酒渣鼻患者的抑郁症和焦虑症。
