Goujard J
INSERM, U 149, Paris.
Rev Epidemiol Sante Publique. 1988;36(4-5):283-91.
Etiologic research in the field of congenital malformations, besides specific difficulties, meets the usual methodologic problems in the study of uncommon phenomena. In this situation, registries may be valuable tools due to their specific way of functioning. They appear optimal for an urgent evaluation of an environmental risk. Due to the material available, they are also efficient for analytic research, especially in the frame of international collaboration. This etiological approach, which is not the primary aim of registries of congenital malformations, seems indeed a supplementary contribution to take into account in a cost/benefit evaluation of the epidemiological instrument.
先天性畸形领域的病因学研究，除了存在特定困难外，还面临着研究罕见现象时常见的方法学问题。在这种情况下，登记处因其特殊的运作方式可能成为有价值的工具。它们似乎最适合对环境风险进行紧急评估。基于现有的资料，登记处对于分析性研究也是有效的，特别是在国际合作的框架内。这种病因学研究方法虽然不是先天性畸形登记处的主要目标，但在对流行病学工具进行成本效益评估时，确实似乎是一个应予以考虑的补充因素。
