A Murri Clinica Medica, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Italy; Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Italy; 2nd Medical Department, Emergency Clinic County Hospital, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. .
2nd Medical Department, Emergency Clinic County Hospital, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J Gastrointestin Liver Dis. 2020 Mar 13;29(1):77-83. doi: 10.15403/jgld-352.
Recent mounting evidence suggest that probiotics supplementation can have a positive effect on mood and psychological symptoms such as stress and anxiety disorders. The majority of studies, however, rely on animal models, while clinical data are still inconsistent. In this systematic review, we examined if and to which extent probiotics can influence psychological stress and anxiety disorders.
The search of online databases Medline, PubMed, Scopus, Web of Science and clinical trials.gov provided relevant studies up to November 2019. We included double blind, randomized and placebo controlled or prospective studies, as well as studies measuring preclinical psychological symptoms of perceived stress and anxiety, before and after supplementation with a probiotic.
Twelve studies met the inclusion criteria (3 on stress, 4 on anxiety, and 5 both on stress and anxiety), accounting for 1,521 participants. The improvement of stress, anxiety, and stress-anxiety was reported in 1/3, 3/4, and 2/5 studies, respectively.
Available studies suggest that probiotics may improve psychological symptoms associated particularly with anxiety. Further research needs to investigate whether probiotics also improve psychological stress disturbances.
最近越来越多的证据表明，益生菌补充剂可能对情绪和心理症状（如压力和焦虑障碍）产生积极影响。然而，大多数研究依赖于动物模型，而临床数据仍不一致。在本系统评价中，我们研究了益生菌是否以及在何种程度上可以影响心理压力和焦虑障碍。
通过检索在线数据库 Medline、PubMed、Scopus、Web of Science 和 clinicaltrials.gov，我们获取了截至 2019 年 11 月的相关研究。我们纳入了双盲、随机、安慰剂对照或前瞻性研究，以及在补充益生菌前后测量感知压力和焦虑的临床前心理症状的研究。
符合纳入标准的研究有 12 项（3 项关于压力，4 项关于焦虑，5 项关于压力和焦虑），共纳入 1521 名参与者。分别有 1/3、3/4 和 2/5 的研究报告了压力、焦虑和压力-焦虑的改善。
现有研究表明，益生菌可能改善与焦虑相关的心理症状。需要进一步研究益生菌是否也能改善心理应激障碍。
