Diop Laurent, Guillou Sonia, Durand Henri
Savoir-Faire & Cie, 91400 Saclay, France.
Nutr Res. 2008 Jan;28(1):1-5. doi: 10.1016/j.nutres.2007.10.001.
Stress plays an important role in the development of symptoms contributing to disease. Stress induces various disorders with gastrointestinal, physical, and psychological symptoms. Probiotics can help regulate or modulate gastrointestinal functions. The aim of the present study was to investigate the effects of a probiotic preparation (Probio-Stick) on stress-induced symptoms in volunteers. A double-blind, placebo-controlled, randomized study was conducted on volunteers with symptoms of stress. Subjects received a probiotic (Probio-Stick; Lallemand SAS, Saint-Simon, France) containing Lactobacillus acidophilus Rosell-52 and Bifidobacterium longum Rosell-175 (3 x 10(9) colony-forming units per sachet stick) or a sensorially identical placebo without probiotics during a 3-week period. The consumption of probiotics significantly reduced 2 stress-induced gastrointestinal symptoms (abdominal pain and nausea/vomiting) for intention-to-treat or per-protocol populations. In contrast, the probiotics did not significantly modify the other physical and psychological symptoms and sleep problems induced by stressful life events for intention-to-treat or per-protocol populations. The results indicate that Probio-Stick can provide a beneficial effect on the gastrointestinal symptoms experienced by individuals affected by chronic stress.
压力在导致疾病的症状发展过程中起着重要作用。压力会引发各种伴有胃肠道、身体和心理症状的紊乱。益生菌有助于调节胃肠道功能。本研究的目的是调查一种益生菌制剂（益生菌棒）对志愿者压力诱导症状的影响。对有压力症状的志愿者进行了一项双盲、安慰剂对照、随机研究。在为期3周的时间里，受试者接受了一种含有嗜酸乳杆菌Rosell - 52和长双歧杆菌Rosell - 175（每支棒状包装含3×10⁹菌落形成单位）的益生菌（益生菌棒；拉曼德公司，法国圣西门），或一种不含益生菌但感官上相同的安慰剂。对于意向性分析人群或符合方案人群，食用益生菌显著减轻了2种压力诱导的胃肠道症状（腹痛和恶心/呕吐）。相比之下，对于意向性分析人群或符合方案人群，益生菌并未显著改善由压力性生活事件引起的其他身体和心理症状及睡眠问题。结果表明，益生菌棒对受慢性压力影响的个体所经历的胃肠道症状具有有益作用。
