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挖掘蛋白纳米制剂的奥秘。

Dig & Delve into Protein Based Nanoformulations.

机构信息

Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

出版信息

Drug Res (Stuttg). 2020 May;70(5):183-187. doi: 10.1055/a-1127-2960. Epub 2020 Mar 16.

Abstract

Past few decades have emerged as the era of nanotechnology worldwide leading to an extensive research in pharmaceutical science as well as other fields. Nanoformulations have shown a promising future in therapeutics and theronostics. Protein based nanoformulations attracting attention in research as it can be used as therapeutics as well as carrier. Carrier based protein nanoformulatios are capable of accommodating range of therapeutics such as dyes, drugs, contrast agents and inorganic nanoclusters makings its application vast. The nano size of formulation enables it to reach the desired places by some modification. This paper reviewed the various protein based nanoformulation. Human serum albumin, Bovine serum albumin, soy protein isolate, phycocyanin, casein, bromelein, collagen and sericin based nanoformulations are briefly discussed. Various limitations of these proteins can be diminished by developing it in nano form and emerged as promising candidate as carrier as well as therapeutics in drug delivery advancements.

摘要

过去几十年是全球纳米技术的时代,这导致了在制药科学及其他领域的广泛研究。纳米制剂在治疗学和治疗学方面显示出了广阔的前景。基于蛋白质的纳米制剂在研究中引起了关注,因为它既可以用作治疗剂,也可以用作载体。基于载体的蛋白质纳米制剂能够容纳多种治疗剂,如染料、药物、对比剂和无机纳米簇,从而使其应用广泛。制剂的纳米尺寸使其能够通过一些修饰到达所需的位置。本文综述了各种基于蛋白质的纳米制剂。简要讨论了人血清白蛋白、牛血清白蛋白、大豆分离蛋白、藻蓝蛋白、酪蛋白、菠萝蛋白酶、胶原蛋白和丝胶蛋白的纳米制剂。通过将这些蛋白质制成纳米形式,可以减少其各种局限性,并作为载体和治疗剂在药物输送的发展中成为有前途的候选者。

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