Lopalco Antonio, Denora Nunzio
Department of Pharmacy-Drug Sciences, The University of Bari Aldo Moro, Bari, Italy.
Methods Mol Biol. 2018;1800:347-365. doi: 10.1007/978-1-4939-7899-1_17.
This chapter presents an outline of the recent available information regarding safety, toxicity, and efficacy of nano drug delivery systems. Of particular importance is the evaluation of several key factors to design nontoxic and effective nanoformulations. Among them, we focus on nanostructure materials and synthesis methods, mechanisms of interactions with biological systems, treatment of nanoparticles, manufacture impurities, and nanostability. Emphasis is given to in silico, in vitro, and in vivo models used to assess and predict the toxicity of these new formulations. Additionally, some examples of in vitro and in vivo studies of specific nanoderivatives are also presented in this chapter.
本章概述了有关纳米药物递送系统的安全性、毒性和有效性的最新可用信息。设计无毒且有效的纳米制剂时，评估几个关键因素尤为重要。其中，我们重点关注纳米结构材料和合成方法、与生物系统的相互作用机制、纳米颗粒的处理、制造杂质和纳米稳定性。重点介绍了用于评估和预测这些新制剂毒性的计算机模拟、体外和体内模型。此外，本章还给出了特定纳米衍生物的体外和体内研究的一些实例。
