血清缺糖转铁蛋白与过量饮酒其他生物学标志物的比较。

A comparison of serum carbohydrate-deficient transferrin with other biological markers of excessive drinking.

作者信息

Gjerde H, Johnsen J, Bjørneboe A, Bjørneboe G E, Mørland J

机构信息

National Institute of Forensic Toxicology, Oslo, Norway.

出版信息

Scand J Clin Lab Invest. 1988 Feb;48(1):1-6. doi: 10.3109/00365518809085386.

DOI:10.3109/00365518809085386

PMID:3217743

Abstract

In a study of suggested biological markers of excessive drinking, serum carbohydrate-deficient transferrin (CDT) was compared with serum activities of alanine aminotransferase, alkaline phosphatase, amylase, aspartate aminotransferase and gamma glutamyltransferase; serum concentrations of high-density lipoprotein cholesterol; and erythrocyte mean cellular volume. Analytical data were studied in relation to self-reported alcohol consumption during the latest month for the 69 participating subjects. CDT was found to be the most sensitive and most specific marker of excessive drinking, and was also found to be the best marker for monitoring abstinence under treatment of alcoholics.

摘要

在一项关于过量饮酒的潜在生物学标志物的研究中，将血清缺糖转铁蛋白（CDT）与丙氨酸转氨酶、碱性磷酸酶、淀粉酶、天冬氨酸转氨酶和γ-谷氨酰转移酶的血清活性；高密度脂蛋白胆固醇的血清浓度；以及红细胞平均细胞体积进行了比较。针对69名参与研究的受试者，研究了与他们最近一个月自我报告的酒精摄入量相关的分析数据。结果发现，CDT是过量饮酒最敏感、最具特异性的标志物，也是监测酗酒者治疗期间戒酒情况的最佳标志物。