Godsell P A, Whitfield J B, Conigrave K M, Hanratty S J, Saunders J B
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Alcohol Alcohol. 1995 Jan;30(1):61-6.
Little information is available on the value of carbohydrate deficient transferrin (CDT) in detecting persons with hazardous alcohol consumption. In the present study isoelectric focusing (IEF) and immunofixation were used to examine the sensitivity of CDT in hazardous drinkers compared with control subjects and alcohol dependent persons. Elevated CDT levels (> 100 mg/l) were found in 62% of hazardous drinkers and 67% of alcohol dependent persons compared with only 5% of controls. CDT was more sensitive than serum gamma glutamyltransferase (GGT) activity in detecting hazardous alcohol consumption (sensitivity of GGT 19%; P < 0.001), but was of comparable sensitivity to GGT for alcohol dependence. Neither the transferrin index nor transferrin ratio offered any advantage over CDT in detecting hazardous consumption. We conclude that serum CDT, as measured by IEF and immunofixation, is a sensitive and specific test for hazardous drinking.
关于缺糖转铁蛋白（CDT）在检测有危险饮酒行为者方面的价值，目前可获取的信息较少。在本研究中，采用等电聚焦（IEF）和免疫固定法来检测CDT在危险饮酒者中的敏感性，并与对照组和酒精依赖者进行比较。与仅5%的对照组相比，62%的危险饮酒者和67%的酒精依赖者的CDT水平升高（>100mg/l）。在检测危险饮酒行为时，CDT比血清γ-谷氨酰转移酶（GGT）活性更敏感（GGT的敏感性为19%；P<0.001），但在检测酒精依赖方面，其敏感性与GGT相当。在检测危险饮酒行为时，转铁蛋白指数和转铁蛋白比率均未显示出比CDT有任何优势。我们得出结论，通过IEF和免疫固定法测定的血清CDT是一种检测危险饮酒行为的敏感且特异的检测方法。
