Lauper M, Castelli D, Buchs J, Pichler W, Nydegger U
Hämatologisches Zentrallabor, Universität Bern.
Schweiz Med Wochenschr. 1988 Dec 10;118(49):1847-50.
Circulating immune complexes and platelet associated immunoglobulins G (PAIgG) were measured in 14 clinically asymptomatic and 9 diseased HIV infected subjects and compared to their platelet counts in the peripheral blood. In both groups, circulating immune complexes were found to be increased even in the presence of normal platelet counts. Increased PAIgG levels were found in symptomatic HIV infected subjects, along with thrombocytopenia. This study indicates that the mere occurrence of circulating immune complexes is an insufficient finding for induction of thrombocytopenia. Either the molecular composition of the complexes is different in both patient groups, or the thrombocytopenia is induced by additional platelet damaging compounds, e.g. specific antiplatelet antibodies induced by the viral infection.
在14名临床无症状的HIV感染者和9名患病的HIV感染者中检测了循环免疫复合物和血小板相关免疫球蛋白G（PAIgG），并将其与外周血中的血小板计数进行比较。在两组中，即使血小板计数正常，循环免疫复合物也有所增加。有症状的HIV感染者中发现PAIgG水平升高，同时伴有血小板减少。这项研究表明，仅循环免疫复合物的出现不足以导致血小板减少。要么两组患者中复合物的分子组成不同，要么血小板减少是由其他血小板损伤化合物引起的，例如病毒感染诱导产生的特异性抗血小板抗体。
