Fabris F, Cordiano I, Casonato A, Zanon E, Luzzatto G, Girolami A
University of Padua Medical School, Institute of Medical Semeiotics, Italy.
Folia Haematol Int Mag Klin Morphol Blutforsch. 1990;117(5):709-16.
We have studied anti platelet antibodies and circulating immunocomplexes in 16 haemophiliacs with mild thrombocytopenia eight of which were infected by human immunodeficiency virus (HIV). No difference in platelet count was observed between HIV+ (143 +/- 31 x 10(9)/l) and HIV- patients (148 +/- 30 x 10(9)/l). On the contrary, HIV+ haemophiliacs had serum platelet bindable IgG (SPBIgG), normal platelet associated IgG (PAIgG), high serum IgG and circulating immunocomplexes (CIC). Considering all 16 patients serum IgG correlated with CIC (r = 0.7 p less than 0.01) and SPBIgG (r = 0.6 p less than 0.01) respectively. We obtained also a positive correlation between serum CIC and SPBIgG (r = 0.51 p less than 0.05). Immunoblotting of patients' sera showed no specific binding to target platelet antigens. In conclusion there is no evidence of HIV related immune thrombocytopenia in our haemophiliacs but the study confirms the appearance of immunocomplexes in the HIV+ subjects.
我们研究了16例轻度血小板减少症血友病患者的抗血小板抗体和循环免疫复合物，其中8例感染了人类免疫缺陷病毒（HIV）。HIV阳性患者（143±31×10⁹/L）和HIV阴性患者（148±30×10⁹/L）的血小板计数未见差异。相反，HIV阳性血友病患者血清中可与血小板结合的IgG（SPBIgG）正常，血小板相关IgG（PAIgG）正常，但血清IgG和循环免疫复合物（CIC）水平较高。综合所有16例患者来看，血清IgG分别与CIC（r = 0.7，p＜0.01）和SPBIgG（r = 0.6，p＜0.01）相关。血清CIC与SPBIgG之间也呈正相关（r = 0.51，p＜0.05）。患者血清免疫印迹显示未与靶血小板抗原发生特异性结合。总之，在我们的血友病患者中没有证据表明存在HIV相关的免疫性血小板减少症，但该研究证实了HIV阳性受试者中出现免疫复合物。
