Exquis B, Perrin L, Link L, Scrignari V, Hirschel B, Zubler R, Miescher P A
Division d'hématologie, Hôpital cantonal universitaire, Genève.
Schweiz Med Wochenschr. 1987 Nov 21;117(47):1863-5.
87 patients with anti-HIV antibodies were divided into three groups based on the classification of the Centers for Disease Control and the following parameters reflecting polyclonal B cell activation were evaluated in these patients: immunoglobulin levels, circulating immune complexes and occurrence of autoantibodies. The results reported here indicate that intense polyclonal B cell activation occurs in both asymptomatic (CDC 2) and symptomatic patients (CDC 3 and CDC 4). Moreover, serological abnormalities were detected with similar frequency in the three groups studied.
87名抗HIV抗体阳性患者根据疾病控制中心的分类标准分为三组，并对这些患者评估了以下反映多克隆B细胞活化的参数：免疫球蛋白水平、循环免疫复合物及自身抗体的出现情况。本文报道的结果表明，无症状（疾病控制中心2级）和有症状患者（疾病控制中心3级和4级）均发生了强烈的多克隆B细胞活化。此外，在所研究的三组中检测到血清学异常的频率相似。
