FASN 在富含恶性神经胶质瘤衍生细胞外囊泡的生物标志物中富集。
FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles.
机构信息
Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
出版信息
Int J Mol Sci. 2020 Mar 12;21(6):1931. doi: 10.3390/ijms21061931.
Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs.
细胞外囊泡 (EVs) 在癌症进展中起着重要作用，并且作为肿瘤生物标志物的来源具有很大的潜力。然而，由于正常宿主细胞来源的 EV 污染，从患者血浆中纯化肿瘤特异性 EV 仍然是一个迫切未满足的需求，这导致分析灵敏度受损。在这里，我们发现脂肪酸合酶 (FASN)，一种在恶性神经胶质瘤细胞中高度表达的关键脂肪生成酶，在神经胶质瘤患者血浆样本的 CD63-和 CD81-阳性 EV 中升高，为分选脑肿瘤特异性 EV 提供了重要机会。
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