Abels Erik R, Broekman Marike L D, Breakefield Xandra O, Maas Sybren L N
Departments of Neurology and Radiology, Massachusetts General Hospital, Boston, MA 02129, USA; NeuroDiscovery Center, Harvard Medical School, Boston, MA 02115, USA.
Departments of Neurology and Radiology, Massachusetts General Hospital, Boston, MA 02129, USA; NeuroDiscovery Center, Harvard Medical School, Boston, MA 02115, USA; Department of Neurosurgery, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands; Department of Neurosurgery, Haaglanden Medical Center, 2512 VA, The Hague, The Netherlands.
Trends Cancer. 2019 Jul;5(7):393-396. doi: 10.1016/j.trecan.2019.05.006. Epub 2019 Jun 4.
Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.
胶质母细胞瘤细胞释放细胞外囊泡（EVs），有时也称为微泡和外泌体，将免疫调节分子传递给免疫细胞，从而形成免疫特权微环境。在此，我们讨论了胶质瘤免疫调节潜在的EV介导机制，以及研究这些相互作用时遇到的技术难题。
