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一名免疫功能低下且腹泻患者的病例。 (你提供的原文“A Case of in an Immunocompromised Patient with Diarrhea.”似乎不完整,少了关键病症等信息,但按照要求进行了翻译)

A Case of in an Immunocompromised Patient with Diarrhea.

作者信息

Fernández-Bravo Ana, Fort-Gallifa Isabel, Ballester Frederic, Pujol Isabel, Gomez-Bertomeu Frederic, Domínguez Mariola, Micó Miquel, Alcoceba Eva, Simó-Sisó Josep Maria, Figueras Maria José

机构信息

Unidad de Microbiología, Departamento de Ciencias Médicas Básicas, Facultad de Medicina y Ciencias de la Salud, IISPV, Universidad Rovira i Virgili, Reus 43201, Spain.

Hospital Universitari Sant Joan de Reus-Laboratori de Referència de Tarragona i Terres de l'Ebre, Reus 43201, Spain.

出版信息

Microorganisms. 2020 Mar 12;8(3):399. doi: 10.3390/microorganisms8030399.

Abstract

According to recent literature, 95.4% of the strains associated with human clinical cases correspond to four species: , , and However, other less prevalent species such as are also described from clinical samples. Based on its low incidence, the latter species can be regarded as rare and it is the only species susceptible to ampicillin. From the taxonomic point of view, is considered a synonym of the species The objective of this study is to present a new clinical case associated with in order to increase the knowledge about this species The strain was recovered from the feces of a 69-year-old patient with a diarrheal syndrome and peritoneal psammocarcinoma. The preliminary identification as sp. was obtained with the API 20E, but it was characterized as and also as with different scores with the matrix-assisted laser desorption ionization time of flight (MALDI-TOF). Based on the sequence of the gene, it was confirmed to be . The antimicrobial resistance pattern showed that the strain was susceptible to ampicillin, penicillins in combination with beta-lactamase inhibitors, quinolones, carbapenems, aminoglycosides and cephalosporins, except cephalothin. In conclusion, the recognition of an strain susceptible to ampicillin should alert the clinical microbiologist of the possible involvement of this rare species. Furthermore, the MALDI-TOF database should be updated indicating that the species , is a synonym of .

摘要

根据最近的文献,与人类临床病例相关的菌株中有95.4%属于四个物种: 、 、 和 。然而,也有从临床样本中分离出的其他不太常见的物种,如 。基于其低发病率,后一种物种可被视为罕见物种,并且它是唯一对氨苄西林敏感的 物种。从分类学角度来看, 被认为是 物种的同义词。本研究的目的是报告一例与 相关的新临床病例,以增加对该物种的了解。该菌株从一名患有腹泻综合征和腹膜沙样癌的69岁患者的粪便中分离得到。通过API 20E初步鉴定为 属,但用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF)以不同分数鉴定为 ,也鉴定为 。基于 基因序列,证实为 。抗菌药物耐药模式显示该菌株对氨苄西林、青霉素与β-内酰胺酶抑制剂的组合、喹诺酮类、碳青霉烯类、氨基糖苷类和头孢菌素类敏感,但对头孢噻吩耐药。总之,识别出一株对氨苄西林敏感的 菌株应提醒临床微生物学家注意这种罕见物种可能的感染情况。此外,MALDI-TOF数据库应更新,表明 物种是 的同义词。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/363f/7143958/fc6da2a1d397/microorganisms-08-00399-g001.jpg

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