Twetman S, Dahllöf G, Lindqvist L
Department of Pedodontics, Karolinska Institute, Huddinge University Hospital, Sweden.
Swed Dent J. 1988;12(5):213-6.
The effect of lysozyme-inactivation on L(+)-lactic acid (LA) production in dental plaque suspensions was evaluated. From 10 children 24-h plaque was collected and lysozyme activity inhibited by addition of goat antiserum to human lysozyme. Acid production was stimulated by addition of glucose. The results showed significantly increased LA levels (50-150%) in lysozyme-inactivated plaque suspensions from 8 of the subjects compared to untreated controls. The increase in acid production activity was not related to plaque lysozyme levels. The findings indicate that the presence of lysozyme may be limiting on acid production in the early dental plaque.
评估了溶菌酶失活对牙菌斑悬液中L(+)-乳酸（LA）产生的影响。从10名儿童中收集24小时的牙菌斑，并通过添加抗人溶菌酶的山羊抗血清来抑制溶菌酶活性。通过添加葡萄糖来刺激酸的产生。结果显示，与未处理的对照组相比，8名受试者的溶菌酶失活牙菌斑悬液中的LA水平显著增加（50-150%）。产酸活性的增加与牙菌斑溶菌酶水平无关。这些发现表明，溶菌酶的存在可能会限制早期牙菌斑中的酸产生。
