Gaponova M V, Shakalis D A, Maliutina S K
Ter Arkh. 1988;60(9):102-6.
Changes in the activity of blood monocytic cholesterol esterase in men with major CHD risk factors (dyslipoproteinemia, arterial hypertension, excessive body mass) were described. Standard methods of epidemiological survey and a radionuclide method to determine cholesterol esterase activity applied to a representative sampling (195 persons) have shown that enzymatic activity was growing with age. In examinees with hyperlipoproteinemia of type IIa and IIb the activity of cholesterol esterase was decreased, and in persons with excessive body mass it was increased. In combination of 2-3 CHD risk factors significant differences in enzymatic activity were undetectable.
描述了患有主要冠心病危险因素（血脂蛋白异常血症、动脉高血压、体重超标）男性的血液单核细胞胆固醇酯酶活性变化。采用流行病学调查的标准方法以及用于确定胆固醇酯酶活性的放射性核素方法，对具有代表性的样本（195人）进行检测，结果表明酶活性随年龄增长而升高。在患有IIa型和IIb型高脂蛋白血症的受检者中，胆固醇酯酶活性降低，而在体重超标的人群中，该酶活性升高。在同时存在2 - 3种冠心病危险因素的情况下，未检测到酶活性存在显著差异。
