Nimptsch Katharina, Jaeschke Lina, Chang-Claude Jenny, Kaaks Rudolf, Katzke Verena, Michels Karin B, Franzke Claus-Werner, Obi Nadia, Becher Heiko, Kuß Oliver, Schikowski Tamara, Schulze Matthias B, Gastell Sylvia, Hoffmann Wolfgang, Schipf Sabine, Ahrens Wolfgang, Günther Kathrin, Krist Lilian, Keil Thomas, Jöckel Karl-Heinz, Schmidt Börge, Brenner Hermann, Holleczek Bernd, Fischer Beate, Leitzmann Michael, Lieb Wolfgang, Berger Klaus, Krause Gérard, Löffler Markus, Schmidt-Pokrzywniak Andrea, Mikolajczyk Rafael, Linseisen Jakob, Greiser Karin Halina, Pischon Tobias
Forschergruppe Molekulare Epidemiologie, Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Deutschland.
Abteilung Epidemiologie von Krebserkrankungen, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020 Apr;63(4):385-396. doi: 10.1007/s00103-020-03113-y.
In the German National Cohort (NAKO Gesundheitsstudie), the largest prospective cohort study in Germany, data on self-reported cancer diagnoses are now available for the first half of participants.
Description of the methods to assess self-reported cancer diagnoses and type of cancer in the NAKO and presentation of first results.
In a computer-assisted, standardized personal interview, 101,787 participants (54,526 women, 47,261 men) were asked whether they had ever been diagnosed with cancer (malignant tumors including in situ) by a physician and how many cancer diagnoses they had. The type of cancer was classified with a list. Absolute and relative frequencies of self-reported cancer diagnoses and types of cancer were calculated and compared with cancer registry data.
A physician-diagnosed cancer was reported by 9.4% of women and 7.0% of men. Of the participants who reported a cancer diagnosis, 88.3% reported to have had only one cancer diagnosis. In women, the most frequent malignancies were breast cancer, cervical cancer, and melanoma. In men, the most frequent malignancies were prostate cancer, melanoma, and colorectal cancer. Comparing the frequencies of cancer diagnoses reported by 45- to 74-year-old NAKO participants within the last five years to cancer registry-based 5‑year prevalences, most types of cancer were less frequent in the NAKO, with the exception of melanoma in men and women, cervical cancer and liver cancer in women, and bladder cancer and breast cancer in men.
The NAKO is a rich data basis for future investigations of incident cancer.
在德国最大的前瞻性队列研究——德国国民队列研究（NAKO健康研究）中，现已获得了首批参与者自我报告癌症诊断的数据。
描述在NAKO中评估自我报告癌症诊断和癌症类型的方法，并展示初步结果。
在一次计算机辅助的标准化个人访谈中，询问了101,787名参与者（54,526名女性，47,261名男性）是否曾被医生诊断患有癌症（包括原位恶性肿瘤）以及他们有过多少次癌症诊断。使用一份清单对癌症类型进行分类。计算自我报告癌症诊断和癌症类型的绝对频率和相对频率，并与癌症登记数据进行比较。
9.4%的女性和7.0%的男性报告有医生诊断的癌症。在报告有癌症诊断的参与者中，88.3%报告仅有一次癌症诊断。在女性中，最常见的恶性肿瘤是乳腺癌、宫颈癌和黑色素瘤。在男性中，最常见的恶性肿瘤是前列腺癌、黑色素瘤和结直肠癌。将NAKO中45至74岁参与者在过去五年中报告的癌症诊断频率与基于癌症登记的5年患病率进行比较，除了男性和女性的黑色素瘤、女性的宫颈癌和肝癌以及男性的膀胱癌和乳腺癌外，NAKO中大多数癌症类型的频率较低。
NAKO是未来对新发癌症进行调查的丰富数据基础。
