Jaeschke Lina, Steinbrecher Astrid, Greiser Karin Halina, Dörr Marcus, Buck Thomas, Linseisen Jakob, Meisinger Christa, Ahrens Wolfgang, Becher Heiko, Berger Klaus, Braun Bettina, Brenner Hermann, Castell Stefanie, Fischer Beate, Franzke Claus-Werner, Gastell Sylvia, Günther Kathrin, Hoffmann Wolfgang, Holleczek Bernd, Jagodzinski Annika, Kaaks Rudolf, Kluttig Alexander, Krause Gérard, Krist Lilian, Kuß Oliver, Lehnich Anna-Therese, Leitzmann Michael, Lieb Wolfgang, Löffler Markus, Michels Karin B, Mikolajczyk Rafael, Peters Annette, Schikowski Tamara, Schipf Sabine, Schmidt Börge, Schulze Matthias, Völzke Henry, Willich Stefan N, Pischon Tobias
Forschergruppe Molekulare Epidemiologie, Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Deutschland.
Abteilung Epidemiologie von Krebserkrankungen, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2020 Apr;63(4):439-451. doi: 10.1007/s00103-020-03108-9.
Data on self-reported cardiovascular and metabolic diseases are available for the first 100,000 participants of the population-based German National Cohort (GNC, NAKO Gesundheitsstudie).
To describe assessment methods and the frequency of self-reported cardiovascular and metabolic diseases in the German National Cohort.
Using a computer-based, standardized personal interview, 101,806 participants (20-75 years, 46% men) from 18 nationwide study centres were asked to use a predefined list to report medical conditions ever diagnosed by a physician, including cardiovascular or metabolic diseases. For the latter, we calculated sex-stratified relative frequencies and compared these with reference data.
With regard to cardiovascular diseases, 3.5% of men and 0.8% of women reported to have ever been diagnosed with a myocardial infarction, 4.8% and 1.5% with angina pectoris, 3.5% and 2.5% with heart failure, 10.1% and 10.4% with cardiac arrhythmia, 2.7% and 1.8% with claudicatio intermittens, and 34.6% and 27.0% with arterial hypertension. The frequencies of self-reported diagnosed metabolic diseases were 8.1% and 5.8% for diabetes mellitus, 28.6% and 24.5% for hyperlipidaemia, 7.9% and 2.4% for gout, and 10.1% and 34.3% for thyroid diseases. Observed disease frequencies were lower than reference data for Germany.
In the German National Cohort, self-reported cardiovascular and metabolic diseases diagnosed by a physician are assessed from all participants, therefore representing a data source for future cardio-metabolic research in this cohort.
基于人群的德国国民队列（GNC，NAKO健康研究）的前100,000名参与者有自我报告的心血管和代谢疾病数据。
描述德国国民队列中自我报告的心血管和代谢疾病的评估方法及频率。
通过基于计算机的标准化个人访谈，来自18个全国性研究中心的101,806名参与者（20 - 75岁，46%为男性）被要求使用预定义列表报告曾被医生诊断的疾病情况，包括心血管或代谢疾病。对于后者，我们计算了按性别分层的相对频率，并将其与参考数据进行比较。
关于心血管疾病，3.5%的男性和0.8%的女性报告曾被诊断为心肌梗死，4.8%和1.5%曾患心绞痛，3.5%和2.5%曾患心力衰竭，10.1%和10.4%曾患心律失常，2.7%和1.8%曾患间歇性跛行，34.6%和27.0%曾患动脉高血压。自我报告的已诊断代谢疾病的频率分别为糖尿病8.1%和5.8%，高脂血症28.6%和24.5%，痛风7.9%和2.4%，甲状腺疾病10.1%和34.3%。观察到疾病频率低于德国的参考数据。
在德国国民队列中，所有参与者均接受了由医生诊断的自我报告的心血管和代谢疾病评估，因此是该队列未来心脏代谢研究的一个数据源。
