黑棘皮病和皮赘与胰岛素抵抗的关联：一项基于印度北部医院的横断面研究。
Association of Acanthosis Nigricans and Acrochordon with Insulin Resistance: A Cross-Sectional Hospital-Based Study from North India.
作者信息
Singh Satyendra K, Agrawal Neeraj K, Vishwakarma Ajay K
机构信息
Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
出版信息
Indian J Dermatol. 2020 Mar-Apr;65(2):112-117. doi: 10.4103/ijd.IJD_646_18.
BACKGROUND
Insulin resistance (IR) is a pre-diabetic condition and has been reported in patients with acanthosis nigricans (AN) and acrochordon. AN and acrochordon are claimed to be cutaneous markers of IR.
AIM
The purpose of this paper was to study the association of AN and acrochordon with IR.
METHODS
It was a cross-sectional hospital-based study. Both groups were assessed for IR by using homeostatic model assessment of insulin resistance (HOMA-IR) formula.
RESULTS
A total of 70 cases and an equal number of controls were studied. IR was observed more in cases (41.4%) compared to controls (17.1%) ( < 0.01). Mean HOMA-IR value was also significantly higher in cases (4.32 ± 4.44) compared to controls (2.27 ± 0.90) ( < 0.05).
LIMITATIONS
Low number of cases and controls were taken in the study. Association with hyperlipidemia and metabolic syndrome was not elicited.
CONCLUSIONS
AN and acrochordons were found to be associated with IR.
背景
胰岛素抵抗（IR）是一种糖尿病前期状态，已在黑棘皮病（AN）和皮赘患者中被报道。AN和皮赘被认为是IR的皮肤标志物。
目的
本文旨在研究AN和皮赘与IR之间的关联。
方法
这是一项基于医院的横断面研究。两组均使用胰岛素抵抗稳态模型评估（HOMA-IR）公式评估IR。
结果
共研究了70例病例和数量相等的对照组。与对照组（17.1%）相比，病例组中观察到的IR更多（41.4%）（<0.01）。病例组的平均HOMA-IR值（4.32±4.44）也显著高于对照组（2.27±0.90）（<0.05）。
局限性
本研究纳入的病例和对照数量较少。未探讨与高脂血症和代谢综合征的关联。
结论
发现AN和皮赘与IR有关。
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