Debelo Hawi, Ndiaye Cheikh, Kruger Johanita, Hamaker Bruce R, Ferruzzi Mario G
1Department of Nutrition Science, Purdue University, West Lafayette, IN USA.
2Department of Food, Bioprocessing and Nutrition Science, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC USA.
J Food Sci Technol. 2020 Apr;57(4):1382-1392. doi: 10.1007/s13197-019-04173-y. Epub 2019 Nov 22.
Food-to-food fortification of staple cereal products using nutrient-dense plants shows promise to address multiple micronutrient deficiencies including vitamin A, iron and zinc in Sub-Saharan Africa. However, there is limited information on the potential interaction effects that such food-to-food fortified strategies may have on individual micronutrient bioavailability. The main objective of the current study was to investigate the impact of incorporating (baobab fruit pulp), a mineral-rich plant material, on the delivery of carotenoids from a composite cereal porridge. Formulations of native fruit/vegetable-cereal composites were screened for interactions which could influence both bioaccessibility and subsequent intestinal uptake of provitamin A carotenoids. Proportions of pearl millet flour and plant materials were dry blended to provide composite cereal porridges with total provitamin A carotenoid concentrations ranging from 3590.7 ± 23.4 to 3698.5 ± 26.5 μg/100 g (fw) and baobab concentrations ranging from 0 to 25% (dw).While there were no significant differences in provitamin A carotenoid bioaccessibility from porridge formulations containing 5 or 15% baobab, inclusion of 25% baobab resulted in a significant ( < 0.05) decrease in bioaccessibility (13.3%) as compared to the control (23.8%). Despite the reduced bioaccessibility, 6 h uptake efficiency of provitamin A carotenoids by Caco-2 human intestinal cells was not significantly altered by 25% baobab inclusion. These findings suggest that the inhibitory effects on carotenoid micellarization (bioaccessibility) observed with increased baobab addition may not ultimately limit the bioavailability of carotenoids.
使用营养丰富的植物对主要谷物产品进行食物间强化，有望解决撒哈拉以南非洲地区包括维生素A、铁和锌在内的多种微量营养素缺乏问题。然而，关于这种食物间强化策略可能对个体微量营养素生物利用度产生的潜在相互作用影响的信息有限。本研究的主要目的是调查添加富含矿物质的植物材料（猴面包树果肉）对复合谷物粥中类胡萝卜素传递的影响。对天然水果/蔬菜 - 谷物复合材料配方进行筛选，以寻找可能影响维生素A原类胡萝卜素生物可及性及随后肠道吸收的相互作用。将珍珠粟粉和植物材料按比例干混，制成复合谷物粥，其维生素A原类胡萝卜素总浓度范围为3590.7±23.4至3698.5±26.5μg/100g（鲜重），猴面包树浓度范围为0至25%（干重）。虽然含有5%或15%猴面包树的粥配方中维生素A原类胡萝卜素的生物可及性没有显著差异，但与对照组（23.8%）相比，添加25%猴面包树导致生物可及性显著（<0.05）降低（13.3%）。尽管生物可及性降低，但添加25%猴面包树对Caco - 2人肠道细胞对维生素A原类胡萝卜素的6小时摄取效率没有显著改变。这些发现表明，随着猴面包树添加量增加而观察到的对类胡萝卜素胶束化（生物可及性）的抑制作用可能最终不会限制类胡萝卜素的生物利用度。
