超声辅助下7-氮杂环基氨基-4,5,6,7-四氢氮杂环并[1,5-a]嘧啶的非常规四组分合成

Ultrasonic-assisted unusual four-component synthesis of 7-azolylamino-4,5,6,7-tetrahydroazolo[1,5-]pyrimidines.

作者信息

Sakhno Yana I, Murlykina Maryna V, Zbruyev Oleksandr I, Kozyryev Anton V, Shishkina Svetlana V, Sysoiev Dmytro, Musatov Vladimir I, Desenko Sergey M, Chebanov Valentyn A

机构信息

Division of Chemistry of Functional Materials, State Scientific Institution "Institute for Single Crystals" of National Academy of Sciences of Ukraine, Nauky Av. 60, 61072 Kharkiv, Ukraine.

Faculty of Chemistry, V. N. Karazin Kharkiv National University, Svobody Sq. 4, 61077 Kharkiv, Ukraine.

出版信息

Beilstein J Org Chem. 2020 Feb 27;16:281-289. doi: 10.3762/bjoc.16.27. eCollection 2020.

Four-component reactions of 3-amino-1,2,4-triazole or 5-amino-1-pyrazole-4-carbonitrile with aromatic aldehydes and pyruvic acid or its esters under ultrasonication were studied. Unusual for such a reaction type, a cascade of elementary stages led to the formation of 7-azolylaminotetrahydroazolo[1,5-]pyrimidines.