Sepehri Saghi, Sanchez Horacio Perez, Fassihi Afshin
J Pharm Pharm Sci. 2015;18(1):1-52. doi: 10.18433/j3q01v.
Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4-tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. This is mainly due to the convenient methods that exist for their synthesis and the diverse pharmacologic properties that these scaffolds present. 1,4-Dihydropyridines and 1,2,3,4-tetrahydropyrimidines are usually regarded as analogous in several aspects. They are both prepared in multi-component reactions using very similar starting materials and synthesis protocols. This leads to common structural features between 1,4-DHPs and 1,2,3,4-THPMs, as well several related biological effects. For example, they share many pharmacological features such as analgesic, anti-tumor, antioxidant, anti-inflammatory, antitubercular, antibacterial, cardiovascular and adrenoceptor blocking activities. Numerous reviews have been devoted to the chemistry and cardiovascular effects of these compounds. However, the lack of a comprehensive literature overview on the chemotherapeutic ability of these scaffolds is behind the present attempt to provide a detailed survey of 1,4-DHPs and 1,2,3,4-THPMs and their structural features as chemotherapeutic agents.
在关于1,4 - 二氢吡啶（1,4 - DHPs）和1,2,3,4 - 四氢嘧啶（1,2,3,4 - THPMs）的首篇报道出现多年后，它们作为可能的治疗药物再次受到关注。这主要归因于其存在简便的合成方法以及这些骨架所呈现的多样药理特性。1,4 - 二氢吡啶和1,2,3,4 - 四氢嘧啶通常在几个方面被视为类似物。它们都是在多组分反应中使用非常相似的起始原料和合成方案制备的。这导致了1,4 - DHPs和1,2,3,4 - THPMs之间具有共同的结构特征以及一些相关的生物学效应。例如，它们具有许多药理特性，如镇痛、抗肿瘤、抗氧化、抗炎、抗结核、抗菌、心血管和肾上腺素能受体阻断活性。已有众多综述致力于这些化合物的化学和心血管效应。然而，由于缺乏关于这些骨架作为化疗药物的化疗能力的全面文献综述，才有了本次对1,4 - DHPs和1,2,3,4 - THPMs及其作为化疗药物的结构特征进行详细综述的尝试。
