Lattanzio Silvia Maria, Imbesi Francesca
Department of Biomedical Sciences, University of Padova, Via Marzolo 3, 35131, Padova, Italy.
Neurological Department, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Radiol Case Rep. 2020 Mar 6;15(5):534-541. doi: 10.1016/j.radcr.2020.02.002. eCollection 2020 May.
We report a case of a fibromyalgia (FM) patient with an history of brain-cancer presenting signs and symptoms of gadolinium toxicity following repeated administrations of a macrocyclic contrast agent, Gadovist. In the present report, we provide evidence supporting the hypothesis of a causal relationship linking gadolinium deposition to a clinical manifestation of disease, namely fibromyalgia. We unravel a role for gadolinium in the still unknown etiology of fibromyalgia as a metal toxicity disorder. Contrast agents are routinely administered in a clinical context. It is thus possible that the patients are mistakenly believed to show complaint of their primary disease, whereas, in some instances, their symptoms are associated with gadolinium deposition.
我们报告了一例纤维肌痛（FM）患者，该患者有脑癌病史，在多次使用大环造影剂钆布醇后出现钆中毒的体征和症状。在本报告中，我们提供证据支持钆沉积与一种疾病的临床表现（即纤维肌痛）之间存在因果关系的假设。我们揭示了钆在纤维肌痛仍不明病因中作为一种金属毒性障碍所起的作用。造影剂在临床环境中经常使用。因此，有可能患者被错误地认为是在诉说其原发性疾病，而在某些情况下，他们的症状与钆沉积有关。
