Khelifi Dayssem, Nacef Ibtissem Ben, Rojbi Imen, Mchirgui Nadia, Khiari Karima
Université de Tunis El Manar, Faculté de Médecine de Tunis, Service d'Endocrinologie-Diabétologie, Hôpital Charles Nicolle, Tunis, Tunisie.
Pan Afr Med J. 2019 Dec 30;34:215. doi: 10.11604/pamj.2019.34.215.19988. eCollection 2019.
Clinical manifestations and visceral involvements described in patients with thyroid disease are many and varied. However, cases of patients with hepatic manifestations have been rarely reported in the literature. We here report the case of a 50 year old patient diagnosed with Graves' disease without a goiter or ocular manifestations. Follow-up laboratory testing led to the detection of anicteric cholestasis. Investigations of the potential causes were negative and given the normalization of the liver parameters after appropriate treatment of hyperthyroidism, the diagnosis of hepatic involvement secondary to Graves' disease was retained. The purpose of this study was to report a new case of rare hepatic manifestation (cholestasis anictérique) in a patient with hyperthyroidism: Graves' disease.
甲状腺疾病患者所描述的临床表现和内脏受累情况多种多样。然而，文献中很少报道有肝脏表现的病例。我们在此报告一例50岁的患者，诊断为Graves病，无甲状腺肿大或眼部表现。随访实验室检查发现无黄疸性胆汁淤积。对潜在病因的调查结果为阴性，鉴于甲状腺功能亢进症经适当治疗后肝脏参数恢复正常，故诊断为Graves病继发肝脏受累。本研究的目的是报告一例甲状腺功能亢进症（Graves病）患者罕见肝脏表现（无黄疸性胆汁淤积）的新病例。
