Dang Hongxing, Li Jing, Liu Chengjun, Xu Feng
Department of PICU, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, China.
Front Pediatr. 2020 Feb 28;8:66. doi: 10.3389/fped.2020.00066. eCollection 2020.
Investigate 25-hydroxy vitamin D (25(OH)D) levels and the correlation with cardiovascular sequential organ failure assessment (CV-SOFA) and pediatric risk of mortality III (PRISM-III) scores in critically ill children. This prospective observational cohort study was conducted on consecutive critical ill children aged 1 month to 14 years old in 1 year. The blood sample was collected upon PICU admission. 25(OH)D deficiency was defined as<20 ng/mL. We performed univariate and multivariate analyses to evaluate associations with CV-SOFA and PRISM-III scores and other important outcomes. 296 critically ill children were enrolled in the study. The mean serum 25(OH)D level was 22.5 (IQR 16.3-31.8) ng/mL. The prevalence of 25(OH)D deficiency was 39.2% in critically ill children. 25(OH)D levels were significantly decreased in septic shock and associated with CV-SOFA and PRISM-III scores. In multivariate analysis, vitamin D deficiency is associated with CV-SOFA and PRISM-III scores. 25(OH)D deficiency is prevalent in critically ill children at PICU admission and seems to be associated with higher CV-SOFA and PRISM-III scores. Our study provides additional data for 25 (OH) D statuses that impact the outcomes of critically ill children.
研究危重症儿童的25-羟维生素D（25(OH)D）水平及其与心血管系统序贯器官衰竭评估（CV-SOFA）和小儿死亡风险Ⅲ（PRISM-Ⅲ）评分的相关性。这项前瞻性观察性队列研究在1年内对连续入选的1个月至14岁危重症儿童进行。在患儿入住儿科重症监护病房（PICU）时采集血样。25(OH)D缺乏定义为<20 ng/mL。我们进行单因素和多因素分析以评估其与CV-SOFA和PRISM-Ⅲ评分及其他重要结局的相关性。296名危重症儿童纳入研究。血清25(OH)D平均水平为22.5（四分位间距16.3 - 31.8）ng/mL。危重症儿童中25(OH)D缺乏的患病率为39.2%。脓毒性休克时25(OH)D水平显著降低，且与CV-SOFA和PRISM-Ⅲ评分相关。多因素分析中，维生素D缺乏与CV-SOFA和PRISM-Ⅲ评分相关。入住PICU的危重症儿童中25(OH)D缺乏很普遍，且似乎与更高的CV-SOFA和PRISM-Ⅲ评分相关。我们的研究为影响危重症儿童预后的25(OH)D状态提供了更多数据。
