[Metabolic effects of ethanol and lipid metabolism in the rat liver].

Effect of ethanol intoxication of lipid metabolism in rat liver tissue was studied after daily intraperitoneal administration of 2g ethanol per kg of body mass within a week. Administration of ethanol led to an increase in content of total lipids, cholesterol and triacylglycerides in liver tissue as well as to elevation of relative content of lysophosphatidyl choline and cardiolipin and to a decrease of phosphatidyl choline. Under conditions of the intoxication incorporation of I-14C-acetate into triacylglycerides, phosphatidyl choline and phosphatidyl ethanolamine was decreased mainly as a result of a decrease in specific radioactivity of fatty acids of these lipids.