Selevich M I, Gorenshteĭn B I, Ostrovskiĭ Iu M
Vopr Med Khim. 1993 Jan-Feb;39(1):34-7.
After a single intragastric administration of 25% ethanol in a dose of 1 g/kg of body mass content of total lipids, lysophosphatidyl choline, phosphatidyl ethanolamine and cardiolipin was increased while phosphatidyl choline was decreased in the rat liver tissue. At the same time, there was a decrease in the rate of 2- 14C-acetate incorporation into esters of cholesterol, total phospholipids, lysophosphatidyl choline, sphingomyelin, phosphatidyl ethanolamine and cardiolipin. Administration of ethanolamine simultaneously with ethanol contributed to normalization of the lipid spectrum, impaired by the single ethanol inoculation.
以1 g/kg体重的剂量对大鼠进行单次胃内给予25%乙醇后，大鼠肝脏组织中总脂质、溶血磷脂酰胆碱、磷脂酰乙醇胺和心磷脂的含量增加，而磷脂酰胆碱的含量降低。同时，2-¹⁴C-乙酸掺入胆固醇酯、总磷脂、溶血磷脂酰胆碱、鞘磷脂、磷脂酰乙醇胺和心磷脂的速率降低。乙醇胺与乙醇同时给药有助于使因单次接种乙醇而受损的脂质谱恢复正常。
