肾移植受者长期免疫抑制后 COVID-19 肺炎的成功康复。
Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression.
机构信息
Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Key Laboratory of Organ Transplantation, Ministry of Education, Ministry of Public Health, Chinese Academy of Medical Sciences, Wuhan, China.
出版信息
Am J Transplant. 2020 Jul;20(7):1859-1863. doi: 10.1111/ajt.15869. Epub 2020 Mar 31.
Abstract
The current outbreak of Coronavirus Disease 2019 (COVID-19) has raised great concern worldwide, but its impact on transplant recipients is unknown. We report here the clinical features and therapeutic course of the first reported renal transplant recipient with confirmed COVID-19 pneumonia. This is a 52-year-old man who received kidney transplantation 12 years ago. His overall clinical characteristics (symptoms, laboratory examinations, and chest CT) were similar to those of non-transplanted COVID-19 patients. Following a treatment regimen consisting of reduced immunosuppressant use and low dose methylprednisolone-based therapy, the COVID-19 pneumonia in this long-term immunosuppressive patient was successfully recovered. This effectively treated case has reference value for the future treatment of other transplant patients with COVID-19 pneumonia.
摘要
目前 2019 年冠状病毒病（COVID-19）的爆发引起了全世界的极大关注，但它对移植受者的影响尚不清楚。我们在此报告首例经确认的 COVID-19 肺炎肾移植受者的临床特征和治疗经过。这是一位 52 岁男性，12 年前接受了肾移植。他的整体临床特征（症状、实验室检查和胸部 CT）与非移植 COVID-19 患者相似。在接受减少免疫抑制剂使用和低剂量甲基强的松龙为基础的治疗方案后，这位长期免疫抑制患者的 COVID-19 肺炎成功康复。这一有效治疗的病例对未来治疗其他 COVID-19 肺炎的移植患者具有参考价值。
相似文献
1
Successful recovery of COVID-19 pneumonia in a renal transplant recipient with long-term immunosuppression.肾移植受者长期免疫抑制后 COVID-19 肺炎的成功康复。
Am J Transplant. 2020 Jul;20(7):1859-1863. doi: 10.1111/ajt.15869. Epub 2020 Mar 31.
2
Clinical characteristics and immunosuppressant management of coronavirus disease 2019 in solid organ transplant recipients.实体器官移植受者 2019 冠状病毒病的临床特征和免疫抑制剂治疗。
Am J Transplant. 2020 Jul;20(7):1916-1921. doi: 10.1111/ajt.15928. Epub 2020 May 4.
3
A familial cluster, including a kidney transplant recipient, of Coronavirus Disease 2019 (COVID-19) in Wuhan, China.中国武汉发生的 2019 年冠状病毒病（COVID-19）的一个家族性聚集，包括一名肾移植受者。
Am J Transplant. 2020 Jul;20(7):1869-1874. doi: 10.1111/ajt.15903. Epub 2020 Apr 17.
4
Immunosuppressive therapy maintenance in a kidney transplant recipient with SARS-CoV-2 pneumonia: A case report.肾移植受者 SARS-CoV-2 肺炎的免疫抑制治疗维持：一例报告。
Am J Transplant. 2020 Jul;20(7):1922-1924. doi: 10.1111/ajt.15920. Epub 2020 May 8.
5
Novel coronavirus (SARS-CoV-2) infection in a renal transplant recipient: Case report.肾移植受者新型冠状病毒（SARS-CoV-2）感染：病例报告。
Am J Transplant. 2020 Jul;20(7):1864-1868. doi: 10.1111/ajt.15897. Epub 2020 May 8.
6
Coronavirus Disease 2019 Pneumonia in Immunosuppressed Renal Transplant Recipients: A Summary of 10 Confirmed Cases in Wuhan, China.新型冠状病毒肺炎合并免疫抑制的肾移植受者肺炎：中国武汉 10 例确诊病例总结
Eur Urol. 2020 Jun;77(6):748-754. doi: 10.1016/j.eururo.2020.03.039. Epub 2020 Apr 18.
7
Case report of COVID-19 in a kidney transplant recipient: Does immunosuppression alter the clinical presentation?COVID-19 于肾移植受者中的病例报告：免疫抑制是否改变临床特征？
Am J Transplant. 2020 Jul;20(7):1875-1878. doi: 10.1111/ajt.15874. Epub 2020 Apr 9.
8
Severe COVID-19 in a renal transplant recipient: A focus on pharmacokinetics.肾移植受者的严重 COVID-19：关注药代动力学。
Am J Transplant. 2020 Jul;20(7):1896-1901. doi: 10.1111/ajt.15943. Epub 2020 May 13.
9
Successful treatment of severe COVID-19 pneumonia in a liver transplant recipient.肝移植受者严重 COVID-19 肺炎的成功治疗。
Am J Transplant. 2020 Jul;20(7):1891-1895. doi: 10.1111/ajt.15901. Epub 2020 Apr 19.
10
COVID-19 pneumonia in a kidney transplant recipient successfully treated with tocilizumab and hydroxychloroquine.肾移植受者 COVID-19 肺炎成功接受托珠单抗和羟氯喹治疗。
Am J Transplant. 2020 Jul;20(7):1902-1906. doi: 10.1111/ajt.15935. Epub 2020 May 13.
引用本文的文献
1
Clinical features and outcomes in kidney transplant recipients with COVID-19 pneumonia: a single center retrospective cohort study.COVID-19 肺炎肾移植受者的临床特征和结局：一项单中心回顾性队列研究。
Front Cell Infect Microbiol. 2024 Aug 15;14:1392491. doi: 10.3389/fcimb.2024.1392491. eCollection 2024.
2
Outcome of COVID-19 in Egyptian living-donor kidney transplant recipients and relation to maintenance immunosuppressive drugs: a pilot study.埃及活体供肾移植受者 COVID-19 结局与维持性免疫抑制药物的关系：一项初步研究。
Sci Rep. 2023 Nov 3;13(1):19002. doi: 10.1038/s41598-023-45750-8.
3
Understudied Hyperphosphatemia (Chronic Kidney Disease) Treatment Targets and New Biological Approaches.研究不足的高磷血症（慢性肾脏病）治疗靶点和新的生物学方法。
Medicina (Kaunas). 2023 May 16;59(5):959. doi: 10.3390/medicina59050959.
4
A systematic review and meta-analysis of the seroconversion rates and adverse effects of COVID-19 mRNA vaccine and COVID-19 viral vector vaccine in kidney transplant recipient patients.一项关于 COVID-19 mRNA 疫苗和 COVID-19 病毒载体疫苗在肾移植受者中的血清转化率和不良反应的系统评价和荟萃分析。
Hum Vaccin Immunother. 2023 Dec 31;19(1):2196893. doi: 10.1080/21645515.2023.2196893. Epub 2023 Apr 14.
5
Involvement of epigenetics in affecting host immunity during SARS-CoV-2 infection.表观遗传学在新冠病毒感染过程中影响宿主免疫中的作用。
Biochim Biophys Acta Mol Basis Dis. 2023 Mar;1869(3):166634. doi: 10.1016/j.bbadis.2022.166634. Epub 2022 Dec 26.
6
COVID-19 in Renal Transplant Recipients - A Single Center Experience from India.肾移植受者中的新型冠状病毒肺炎——来自印度一家中心的经验
Indian J Nephrol. 2022 Sep-Oct;32(5):416-422. doi: 10.4103/ijn.IJN_479_20. Epub 2022 Oct 11.
7
Intravenous immunoglobulins: A therapeutic alternative to consider in kidney transplant patients with COVID-19.静脉注射免疫球蛋白：新冠病毒病肾移植患者可考虑的一种治疗选择。
Nefrologia (Engl Ed). 2021 Mar-Apr;41(2):220-222. doi: 10.1016/j.nefroe.2021.04.001. Epub 2021 Apr 22.
8
Solid Organ Rejection following SARS-CoV-2 Vaccination or COVID-19 Infection: A Systematic Review and Meta-Analysis.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗接种或新型冠状病毒肺炎（COVID-19）感染后的实体器官排斥反应：一项系统评价和荟萃分析
Vaccines (Basel). 2022 Aug 10;10(8):1289. doi: 10.3390/vaccines10081289.
9
Covid-19 in kidney transplant recipients with immunosuppressive therapy.接受免疫抑制治疗的肾移植受者中的新冠病毒 19 感染情况。
Caspian J Intern Med. 2022;13(Suppl 3):161-172. doi: 10.22088/cjim.12.4.509.
10
Transplantation in Asia during the coronavirus disease-19 (COVID-19) pandemic: briefs from member countries of the Asian Society of Transplantation.2019冠状病毒病（COVID-19）大流行期间亚洲的移植情况：来自亚洲移植学会成员国的简报
Korean J Transplant. 2020 Jun 30;34(2):71-77. doi: 10.4285/kjt.2020.34.2.71.
本文引用的文献
1
Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.临床证据不支持使用皮质类固醇治疗2019新型冠状病毒肺炎肺损伤。
Lancet. 2020 Feb 15;395(10223):473-475. doi: 10.1016/S0140-6736(20)30317-2. Epub 2020 Feb 7.
2
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.《武汉 2019 年新型冠状病毒感染的肺炎 138 例住院患者临床特征分析》
JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585.
3
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.中国武汉 99 例 2019 年新型冠状病毒肺炎患者的流行病学和临床特征：描述性研究。
Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30.
4
First Case of 2019 Novel Coronavirus in the United States.美国首例 2019 新型冠状病毒病例。
N Engl J Med. 2020 Mar 5;382(10):929-936. doi: 10.1056/NEJMoa2001191. Epub 2020 Jan 31.
5
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany.德国一名无症状接触者传播2019新型冠状病毒感染
N Engl J Med. 2020 Mar 5;382(10):970-971. doi: 10.1056/NEJMc2001468. Epub 2020 Jan 30.
6
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.中国武汉地区 2019 年新型冠状病毒感染患者的临床特征。
Lancet. 2020 Feb 15;395(10223):497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
7
Corticosteroids as adjunctive therapy in the treatment of influenza.皮质类固醇作为流感治疗的辅助疗法。
Cochrane Database Syst Rev. 2019 Feb 24;2(2):CD010406. doi: 10.1002/14651858.CD010406.pub3.
8
Outcomes from pandemic influenza A H1N1 infection in recipients of solid-organ transplants: a multicentre cohort study.实体器官移植受者感染甲型 H1N1 流感的结局：一项多中心队列研究。
Lancet Infect Dis. 2010 Aug;10(8):521-6. doi: 10.1016/S1473-3099(10)70133-X. Epub 2010 Jul 9.
Zotero 插件