Xu Jian-Xing, Zhao Fengqian, Yuan Yang, Wu Xiao-Feng
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
Org Lett. 2020 Apr 3;22(7):2756-2760. doi: 10.1021/acs.orglett.0c00736. Epub 2020 Mar 17.
Herein, we report the first ruthenium-catalyzed Suzuki-type carbonylative reaction of electronically neutral anilines via C(aryl)-N bond cleavage. Without any ligand and base, diaryl ketones can be obtained in moderate to high yields by using Ru(CO) as the catalyst and chelation assisted by pyridine. The pyridine ring has a significant effect on both high efficiency and high regioselectivity in the cleavage of the aryl C-N bond in anilines.
在此，我们报道了首例通过C(芳基)-N键裂解实现的电子中性苯胺的钌催化铃木型羰基化反应。在不使用任何配体和碱的情况下，以Ru(CO)为催化剂，吡啶辅助螯合，可中等至高产率地得到二芳基酮。吡啶环对苯胺中芳基C-N键裂解的高效率和高区域选择性均有显著影响。
