3-取代吲哚的合成：吲哚与芳基碘的铱催化羰基偶联反应。
3-Acylindoles Synthesis: Ruthenium-Catalyzed Carbonylative Coupling of Indoles and Aryl Iodides.
机构信息
Leibniz-Institut für Katalyse e.V. an der Universität Rostock , Albert-Einstein-Straße 29a, 18059 Rostock, Germany.
出版信息
Org Lett. 2017 Sep 1;19(17):4680-4683. doi: 10.1021/acs.orglett.7b02320. Epub 2017 Aug 23.
PMID:28832159
Abstract
A novel and convenient procedure for the synthesis of 3-acylindoles from simple indoles and aryl iodides has been established. Through ruthenium-catalyzed carbonylative C-H functionalization of indoles, with Mo(CO) as the solid CO source, the desired indol-3-yl aryl ketones were isolated in moderate to good yields. Not only N-alkylindoles but also N-H indoles can be applied here.
摘要
已经建立了一种从简单吲哚和芳基碘化物合成 3-酰基吲哚的新颖、简便的方法。通过吲哚的钌催化羰基化 C-H 官能化反应，以 Mo(CO)为固态 CO 源，可从中分离出中等至良好收率的所需吲哚-3-基芳基酮。不仅可以应用 N-烷基吲哚，也可以应用 N-H 吲哚。
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