Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Immunology. 2020 Apr;159(4):355-356. doi: 10.1111/imm.13188.
Both CD8 T cells and NK cells contribute to the immune response against the protozoan Leishmania parasite. Both are able to generate IFN-γ and both display cytotoxic features. These features may enable them to not only contribute to parasite clearance but also to cause immune-mediated pathology. This pathology is evident, for example, in the Leismania-induced skin lesions found in patients with cutaneous leismaniasis (CL). Here we highlight new data demonstrating that CD8 T cells and NK cells in CL display a highly cytotoxic senescent phenotype, and that the senescent T cells play a major role in mediating skin pathology. This is the first demonstration that senescent CD8 T cells contribute to immunopathology in vivo.
CD8 T 细胞和自然杀伤 (NK) 细胞均有助于针对原生动物利什曼原虫寄生虫的免疫反应。它们都能够产生 IFN-γ，并且都具有细胞毒性特征。这些特征使它们不仅能够有助于清除寄生虫，还能够导致免疫介导的病理学。这种病理学在患有皮肤利什曼病 (CL) 的患者中发现的利什曼原虫诱导的皮肤损伤中显而易见。在这里，我们重点介绍新的数据，这些数据表明 CL 中的 CD8 T 细胞和 NK 细胞表现出高度细胞毒性衰老表型，并且衰老的 T 细胞在介导皮肤病理学中起主要作用。这是首次证明衰老的 CD8 T 细胞有助于体内免疫病理学。
