Wang Zhi-Biao, Xu Jing
National Vaccine and Serum Institute, Beijing Economic-Technological Development Area, Beijing 101111, China.
Vaccines (Basel). 2020 Mar 13;8(1):128. doi: 10.3390/vaccines8010128.
Traditional aluminum adjuvants can trigger strong humoral immunity but weak cellular immunity, limiting their application in some vaccines. Currently, various immunomodulators and delivery carriers are used as adjuvants, and the mechanisms of action of some of these adjuvants are clear. However, customizing targets of adjuvant action (cellular or humoral immunity) and action intensity (enhancement or inhibition) according to different antigens selected is time-consuming. Here, we review the adjuvant effects of some delivery systems and immune stimulants. In addition, to improve the safety, effectiveness, and accessibility of adjuvants, new trends in adjuvant development and their modification strategies are discussed.
传统铝佐剂可引发强烈的体液免疫，但细胞免疫较弱，这限制了它们在某些疫苗中的应用。目前，各种免疫调节剂和递送载体被用作佐剂，其中一些佐剂的作用机制已明确。然而，根据所选不同抗原定制佐剂作用的靶点（细胞免疫或体液免疫）和作用强度（增强或抑制）耗时较长。在此，我们综述了一些递送系统和免疫刺激剂的佐剂效应。此外，为提高佐剂的安全性、有效性和可及性，还讨论了佐剂开发的新趋势及其修饰策略。
