Jung Seunggon, Oh Hee-Kyun, Kim Myung-Sun, Lee Ki-Young, Park Hongju, Kook Min-Suk
Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Department of Orthopaedics, School of Medicine, Chonnam National University, Gwangju 61469, Korea.
Materials (Basel). 2020 Mar 14;13(6):1318. doi: 10.3390/ma13061318.
It is necessary to prevent the invasion of soft tissue into bone defects for successful outcomes in guided bone regeneration (GBR). For this reason, many materials are used as protective barriers to bone defects. In this study, a gellan gum/tuna skin gelatin (GEL/TSG) film was prepared, and its effectiveness in bone regeneration was evaluated. The film exhibited average cell viability in vitro. Experimental bone defects were prepared in rabbit calvaria, and a bone graft procedure with beta-tricalcium phosphate was done. The film was used as a membrane of GBR and compared with results using a commercial collagen membrane. Grafted material did not show dispersion outside of bone defects and the film did not collapse into the bone defect. New bone formation was comparable to that using the collagen membrane. These results suggest that the GEL/TSG film could be used as a membrane for GBR.
为了在引导骨再生（GBR）中获得成功的结果，防止软组织侵入骨缺损是必要的。因此，许多材料被用作骨缺损的保护屏障。在本研究中，制备了结冷胶/金枪鱼皮明胶（GEL/TSG）膜，并评估了其在骨再生中的有效性。该膜在体外表现出平均细胞活力。在兔颅骨上制备实验性骨缺损，并进行β-磷酸三钙骨移植手术。该膜用作GBR的膜，并与使用商业胶原膜的结果进行比较。移植材料未显示出在骨缺损外的分散，且该膜未塌陷到骨缺损中。新骨形成与使用胶原膜的情况相当。这些结果表明，GEL/TSG膜可作为GBR的膜使用。
