Wang Bing, Feng Chengmin, Liu Yiming, Mi Fanglin, Dong Jun
Department of Chemistry, School of Pharmacy, North Sichuan Medical College, Nanchong, China.
Department of Otorhinolaryngology & Head Neck Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Jpn Dent Sci Rev. 2022 Nov;58:233-248. doi: 10.1016/j.jdsr.2022.07.002. Epub 2022 Aug 27.
The anatomy of the oral and maxillofacial sites is complex, and bone defects caused by trauma, tumors, and inflammation in these zones are extremely difficult to repair. Among the most effective and reliable methods to attain osteogenesis, the guided bone regeneration (GBR) technique is extensively applied in defective oral and maxillofacial GBR. Furthermore, endowing biofunctions is crucial for GBR materials applied in repairing defective alveolar and maxillofacial bones. In this review, recent advances in designing and fabricating GBR materials applied in oral and maxillofacial sites are classified and discussed according to their biofunctions, including maintaining space for bone growth; facilitating the adhesion, migration, and proliferation of osteoblasts; facilitating the migration and differentiation of progenitor cells; promoting vascularization; providing immunoregulation to induce osteogenesis; suppressing infection; and effectively mimicking natural tissues using graded biomimetic materials. In addition, new processing strategies (e.g., 3D printing) and new design concepts (e.g., developing bone mimetic extracellular matrix niches and preparing scaffolds to suppress connective tissue to actively acquire space for bone regeneration), are particularly worthy of further study. In the future, GBR materials with richer biological functions are expected to be developed based on an in-depth understanding of the mechanism of bone-GBR-material interactions.
口腔颌面部区域的解剖结构复杂，这些部位因创伤、肿瘤和炎症导致的骨缺损极难修复。在实现骨生成的最有效且可靠的方法中，引导骨再生（GBR）技术在口腔颌面部骨缺损修复中得到广泛应用。此外，赋予生物功能对于应用于修复牙槽骨和颌面部骨缺损的GBR材料至关重要。在本综述中，根据其生物功能对应用于口腔颌面部的GBR材料设计与制备的最新进展进行分类和讨论，这些生物功能包括维持骨生长空间；促进成骨细胞的黏附、迁移和增殖；促进祖细胞的迁移和分化；促进血管生成；提供免疫调节以诱导骨生成；抑制感染；以及使用分级仿生材料有效模拟天然组织。此外，新的加工策略（如3D打印）和新的设计理念（如开发仿骨细胞外基质微环境以及制备抑制结缔组织以主动获取骨再生空间的支架）尤其值得进一步研究。未来，有望在深入理解骨 - GBR - 材料相互作用机制的基础上开发出具有更丰富生物功能的GBR材料。
