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新型稠合嘧啶并[2,1-][1,2,4]三唑并[3,4-][1,2,4]三嗪的设计、合成与抗菌评价。

Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-][1,2,4]triazolo[3,4-][1,2,4]triazines.

机构信息

Chemistry Department, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Taif 21974, Saudi Arabia.

On leave from Chemistry Department, Faculty of Science, Aswan University, Aswan P.O. Box 81528, Egypt.

出版信息

Molecules. 2020 Mar 15;25(6):1339. doi: 10.3390/molecules25061339.

DOI:10.3390/molecules25061339
PMID:32183502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7144560/
Abstract

A series of 34 new pyrimido[2,1-][1,2,4]triazine-3,4-diones were synthesized and fully characterized using IR, NMR, MS, and microanalytical analysis. In vitro investigation of 12 compounds of this series revealed promising antimicrobial activity of the conjugates and - that were tagged with electron-withdrawing groups, with sensitivities ranging from 77% to as high as 100% of the positive control. The investigation of antimicrobial activity included ATCC 6633, ATCC 6535, ATCC 27853, and ATCC 8739 (EC), and fungal strains ATCC 10231 and ATCC 16404.

摘要

合成了一系列 34 种新的嘧啶并[2,1-][1,2,4]三嗪-3,4-二酮，并通过红外光谱（IR）、核磁共振（NMR）、质谱（MS）和微量分析进行了全面表征。对该系列的 12 种化合物进行了体外研究，结果表明带有吸电子基团的共轭物 和 具有有前景的抗菌活性，其敏感性范围从 77%到高达 100%的阳性对照。抗菌活性的研究包括 ATCC 6633、ATCC 6535、ATCC 27853 和 ATCC 8739（EC）以及真菌菌株 ATCC 10231 和 ATCC 16404。

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