新型稠合嘧啶并[2,1-][1,2,4]三唑并[3,4-][1,2,4]三嗪的设计、合成与抗菌评价。
Design, Synthesis, and Antimicrobial Evaluation of New Annelated Pyrimido[2,1-][1,2,4]triazolo[3,4-][1,2,4]triazines.
机构信息
Chemistry Department, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Taif 21974, Saudi Arabia.
On leave from Chemistry Department, Faculty of Science, Aswan University, Aswan P.O. Box 81528, Egypt.
出版信息
Molecules. 2020 Mar 15;25(6):1339. doi: 10.3390/molecules25061339.
A series of 34 new pyrimido[2,1-][1,2,4]triazine-3,4-diones were synthesized and fully characterized using IR, NMR, MS, and microanalytical analysis. In vitro investigation of 12 compounds of this series revealed promising antimicrobial activity of the conjugates and - that were tagged with electron-withdrawing groups, with sensitivities ranging from 77% to as high as 100% of the positive control. The investigation of antimicrobial activity included ATCC 6633, ATCC 6535, ATCC 27853, and ATCC 8739 (EC), and fungal strains ATCC 10231 and ATCC 16404.
合成了一系列 34 种新的嘧啶并[2,1-][1,2,4]三嗪-3,4-二酮，并通过红外光谱（IR）、核磁共振（NMR）、质谱（MS）和微量分析进行了全面表征。对该系列的 12 种化合物进行了体外研究，结果表明带有吸电子基团的共轭物 和 具有有前景的抗菌活性，其敏感性范围从 77%到高达 100%的阳性对照。抗菌活性的研究包括 ATCC 6633、ATCC 6535、ATCC 27853 和 ATCC 8739（EC）以及真菌菌株 ATCC 10231 和 ATCC 16404。
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