Department of Interventional Pulmonology and Endoscopic Diagnosis and Treatment Center, Anhui Chest Hospital, Hefei, 230022, Anhui, China.
Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Furong Road no 678, Hefei, 230601, Anhui, China.
Respir Res. 2024 Aug 24;25(1):324. doi: 10.1186/s12931-024-02950-8.
Cobalt (Co) is a metal which is widely used in the industrial production. The previous studies found the toxic effects of environmental Co exposure on multiple organs. However, the correlation of blood Co concentration with lung function was inconsistent in patients with chronic obstructive pulmonary disease (COPD).
All 771 stable COPD patients were recruited. Peripheral blood and clinical information were collected. The levels of blood Co and serum CC16 were measured.
Cross-sectional study suggested that the level of blood Co was inversely and dose-dependently related to lung function parameters. Each 1 ppm elevation of blood Co was related to 0.598 L decline in FVC, 0.465 L decline in FEV1, 6.540% decline in FEV1/FVC%, and 14.013% decline in FEV1%, respectively. Moreover, higher age, enrolled in winter, current-smoking, higher smoking amount, and inhaled corticosteroids prominently exacerbated the negative correlation between blood Co and lung function. Besides, serum CC16 content was gradually reduced with blood Co elevation in COPD patients. Besides, serum CC16 was positively correlated with lung function, and inversely related to blood Co. Additionally, decreased CC16 substantially mediated 11.45% and 6.37% Co-triggered downregulations in FEV1 and FEV1%, respectively.
Blood Co elevation is closely related to the reductions of pulmonary function and serum CC16. CC16 exerts a significantly mediating role of Co-related to pulmonary function decrease among COPD patients.
钴（Co）是一种广泛应用于工业生产的金属。先前的研究发现环境 Co 暴露对多种器官具有毒性作用。然而，在慢性阻塞性肺疾病（COPD）患者中，血液 Co 浓度与肺功能之间的相关性并不一致。
所有 771 例稳定期 COPD 患者均被纳入研究。收集外周血和临床资料，检测血液 Co 水平和血清 CC16 水平。
横断面研究表明，血液 Co 水平与肺功能参数呈负相关且呈剂量依赖性。血液 Co 每升高 1 ppm，与 FVC 下降 0.598 L、FEV1 下降 0.465 L、FEV1/FVC%下降 6.540%、FEV1%下降 14.013%相关。此外，年龄较大、冬季入院、当前吸烟、吸烟量较高和吸入皮质类固醇会显著加重血液 Co 与肺功能之间的负相关关系。此外，COPD 患者的血清 CC16 含量随血液 Co 升高而逐渐降低。此外，血清 CC16 与肺功能呈正相关，与血液 Co 呈负相关。此外，CC16 减少可分别显著介导 11.45%和 6.37%的 Co 导致的 FEV1 和 FEV1%下降。
血液 Co 升高与肺功能下降和血清 CC16 降低密切相关。CC16 在 COPD 患者中对 Co 相关肺功能下降具有显著的中介作用。
