Okan University, Okan University Chest Diseases, İçmeler, Turkey.
Int J Chron Obstruct Pulmon Dis. 2020 Mar 3;15:479-486. doi: 10.2147/COPD.S218785. eCollection 2020.
Emphysema is a progressive and irreversible disease, proceeding with the decrease in elastic recoil which is connected to tissue damage caused by chronic inflammation. Lung volume reduction coil (LVRC) method in patients with an advanced level of emphysema and irresponsive to medical treatment is shown to provide increase in lung volumes and exercise capacity, decrease in dyspnea, and increase in quality of life. The purpose of this study is to reveal that LVRC treatment is also efficient in severe COPD patients with hypercapnic respiratory failure.
Eleven cases with severe COPD and emphysema were included in the study. LVRC treatment method was applied in upper lobes of both lungs in patients with severe COPD (FEV1 < %45) and Type-2 respiratory insufficiency (PCO 55-80 mmHg) who were having medical treatment and CPAP treatment. The patients were followed up for a period of twelve months using arterial blood gas analysis.
Beginning with the first month of the LVRC treatment, PCO levels were found to be significantly decreased in all patients using arterial blood gas analysis.
LVRC method can provide physiological and functional recovery and progress in quality of life in severe COPD cases. It is demonstrated that LVRC treatment caused significant decreases in carbon dioxide levels as well as causing improvement in life quality and respiratory function tests in the patients with hypercapnic respiratory failure.
肺气肿是一种进行性和不可逆转的疾病，其特征是弹性回缩力下降，这与慢性炎症引起的组织损伤有关。对于晚期肺气肿且对药物治疗无反应的患者，肺减容线圈（LVRC）方法已被证明可增加肺容积和运动能力，减轻呼吸困难，并提高生活质量。本研究的目的是证明 LVRC 治疗对伴有高碳酸血症呼吸衰竭的严重 COPD 患者也有效。
本研究纳入了 11 例严重 COPD 和肺气肿患者。LVRC 治疗方法应用于严重 COPD 患者（FEV1<45%）的双肺上叶和 2 型呼吸功能不全（PCO 55-80mmHg）患者，这些患者正在接受药物治疗和 CPAP 治疗。通过动脉血气分析对患者进行为期 12 个月的随访。
从 LVRC 治疗的第一个月开始，所有患者的动脉血气分析均显示 PCO 水平显著降低。
LVRC 方法可提供严重 COPD 患者的生理和功能恢复以及生活质量的提高。LVRC 治疗可显著降低二氧化碳水平，并改善伴有高碳酸血症呼吸衰竭患者的生活质量和呼吸功能测试。
