种子水提取物和布洛芬对胶原诱导性关节炎大鼠软骨组织中炎症基因表达的影响
The Effect of Aqueous Extract of Seeds and Ibuprofen on Inflammatory Gene Expression in the Cartilage Tissue of Rats with Collagen-Induced Arthritis.
作者信息
Korani Mohsen, Jamshidi Mohammadnabi
机构信息
Chemical Injuries Research Center, System Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
出版信息
J Inflamm Res. 2020 Feb 28;13:133-139. doi: 10.2147/JIR.S236242. eCollection 2020.
BACKGROUND AND OBJECTIVES
Rheumatoid arthritis (RA) is an inflammatory disease treated with nonsteroidal anti-inflammatory drugs that have different side effects. One of the plants used for this purpose in the traditional medicine is . The present study aimed at investigating the anti-inflammatory effect of this plant on type II collagen-induced arthritis (CIA) in Wistar rats.
MATERIALS AND METHODS
The study was performed on 35 male Wistar rats. Seven rats were considered as the healthy control group (normal group), and CIA was stablished in the rest. The rats with a model of inflammatory arthritis were divided into four groups. One group did not receive any treatment and three groups were treated orally with ibuprofen (15 mg/kg), aqueous extract of the seeds (100 mg/kg), or their combination for 30 days. The effect of different treatments was investigated on the paw thickness, arthritis score, and mRNA level of and genes.
RESULTS
CIA increased paw thickness, arthritis score, and and mRNA levels compared to those of the normal group. Treatment with ibuprofen and aqueous extract alone or in combination reduced the studied variables. Reduction in the paw thickness, arthritis score, and mRNA level was more in the ibuprofen-treated group than the extract-treated group, but treatment with extract reduced mRNA level more than ibuprofen.
CONCLUSION
It seems that the aqueous extract of can be used alone or in combination with ibuprofen to treat RA.
背景与目的
类风湿关节炎（RA）是一种使用具有不同副作用的非甾体抗炎药进行治疗的炎症性疾病。传统医学中用于此目的的植物之一是[此处原文缺失植物名称]。本研究旨在调查该植物对Wistar大鼠II型胶原诱导性关节炎（CIA）的抗炎作用。
材料与方法
本研究对35只雄性Wistar大鼠进行。7只大鼠被视为健康对照组（正常组），其余大鼠建立CIA模型。将炎性关节炎模型大鼠分为四组。一组不接受任何治疗，三组分别口服布洛芬（15毫克/千克）、[此处原文缺失植物名称]种子水提取物（100毫克/千克）或它们的组合，持续30天。研究了不同治疗方法对 paw厚度、关节炎评分以及[此处原文缺失基因名称]和[此处原文缺失基因名称]基因mRNA水平的影响。
结果
与正常组相比，CIA增加了 paw厚度、关节炎评分以及[此处原文缺失基因名称]和[此处原文缺失基因名称]mRNA水平。单独使用布洛芬和水提取物或联合使用均降低了所研究的变量。布洛芬治疗组 paw厚度、关节炎评分和[此处原文缺失基因名称]mRNA水平的降低幅度大于水提取物治疗组，但水提取物治疗降低[此处原文缺失基因名称]mRNA水平的幅度大于布洛芬。
结论
似乎[此处原文缺失植物名称]水提取物可单独使用或与布洛芬联合使用来治疗RA。
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