FAM64A通过miR-493促进骨肉瘤细胞生长和转移。
FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493.
作者信息
Jiang Ying, Zhou Chunlei, Gao Qiang, Yin Zhi-Qi, Wang Jingwen, Mu Hong, Yan Jun
机构信息
Department of Clinical Laboratory, Tianjin First Center Hospital, Tianjin 300192, China.
Department of Pathology, Tianjin First Center Hospital, Tianjin 300192, China.
出版信息
J Oncol. 2020 Feb 24;2020:2518297. doi: 10.1155/2020/2518297. eCollection 2020.
Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues. Overexpression of FAM64A resulted in promoting tumor proliferation, migration, and invasion. The miR-493 targeted and negatively regulated FAM64A. Our data showed that upregulation of FAM64A in OS correlated with poor prognosis.
FAM64A的异常表达与多种癌症类型的细胞增殖相关。我们检测了骨肉瘤（OS）中FAM64A及上游基因miR-493的表达。通过大量实验揭示了miR-493的功能。我们发现骨肉瘤组织中FAM64A基因和蛋白增加。FAM64A的过表达导致肿瘤增殖、迁移和侵袭增强。miR-493靶向并负向调节FAM64A。我们的数据表明骨肉瘤中FAM64A的上调与预后不良相关。
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